About: No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment     Goto   Sponge   NotDistinct   Permalink

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Description
  • This work was aimed to clarify, whether efavirenz induces ABC-transporters in vivo in PBMCs and whether possible changes in PBMC transporter expression also translate into altered intracellular concentrations of efavirenz. New analytical methods for quantification of efavirenz in plasma, plasma ultrafiltrate and PBMCs were developed. The samples were analyzed by LC/MS/MS.
  • This work was aimed to clarify, whether efavirenz induces ABC-transporters in vivo in PBMCs and whether possible changes in PBMC transporter expression also translate into altered intracellular concentrations of efavirenz. New analytical methods for quantification of efavirenz in plasma, plasma ultrafiltrate and PBMCs were developed. The samples were analyzed by LC/MS/MS. (en)
Title
  • No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment
  • No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment (en)
skos:prefLabel
  • No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment
  • No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment (en)
skos:notation
  • RIV/00216208:11160/10:00300623!RIV11-MSM-11160___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 10
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 274930
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11160/10:00300623
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • efavirenz; ABC-transporters; P-glycoprotein; drug transport; pharmacokinetics (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [B62211746B01]
http://linked.open...i/riv/nazevZdroje
  • Antimicrobial Agents and Chemotherapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 54
http://linked.open...iv/tvurceVysledku
  • Pasáková, Ivana
  • Burhenne, Jürgen
  • Haefeli, Walter Emil
  • Heinrich, Tilman
  • Matthée, Anne-Kathrin
  • Mikus, Gerd
  • Röder, Claudia
  • Weiss, Johanna
http://linked.open...ain/vavai/riv/wos
  • 000281907200020
issn
  • 0066-4804
number of pages
http://localhost/t...ganizacniJednotka
  • 11160
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