About: Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats

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About: Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hepatocellular impairment associated with reduced biliary elimination of methotrexate may contribute to increased hepatotoxicity of the drug when co-administered with dexamethasone. Moreover, an influence of dexamethasone on protein expression of anionic drugs transporters in the liver and kidney was demonstrated. Hepatocellular impairment associated with reduced biliary elimination of methotrexate may contribute to increased hepatotoxicity of the drug when co-administered with dexamethasone. Moreover, an influence of dexamethasone on protein expression of anionic drugs transporters in the liver and kidney was demonstrated. (en)
Title	Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats (en)
skos:prefLabel	Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats (en)
skos:notation	RIV/00216208:11160/10:00300603!RIV11-MSM-11160___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OC09072), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Štaud, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	254041
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/10:00300603
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dexamethasone; methotrexate; conjugated bilirubin; drug transporters; biliary excretion (en)
http://linked.open.../riv/klicoveSlovo	dexamethasone drug transporters methotrexate biliary excretion conjugated bilirubin
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[AFA63838F055]
http://linked.open...i/riv/nazevZdroje	Toxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of TNF-alpha and IL-1 activity as the treatment option during endotoxin induced organ injury.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	267
http://linked.open...iv/tvurceVysledku	Brčáková, Eva Mičuda, Stanislav Kolouchová, Gabriela Hroch, Miloš Štaud, František Cermanová, Jolana Fuksa, Leoš Hiršová, Petra
http://linked.open...ain/vavai/riv/wos	000274588700022
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0300-483X
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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