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  • It is widely believed that P-glycoprotein, together with other ATP efflux drug transporters, plays a crucial role in the host detoxication and protection against xenobiotic substances. On the other hand, the presence of these transporters in normal tissues may prevent pharmacotherapeutic agents from reaching their site of action, thus limiting their therapeutic potential. This review focuses on P-glycoprotein, its expression, localization, and function in nontumor tissues and the pharmacological consequences hereof. Special attention is paid to its role in pharmacokinetics of the small intestine, brain, kidney, liver and placenta.
  • It is widely believed that P-glycoprotein, together with other ATP efflux drug transporters, plays a crucial role in the host detoxication and protection against xenobiotic substances. On the other hand, the presence of these transporters in normal tissues may prevent pharmacotherapeutic agents from reaching their site of action, thus limiting their therapeutic potential. This review focuses on P-glycoprotein, its expression, localization, and function in nontumor tissues and the pharmacological consequences hereof. Special attention is paid to its role in pharmacokinetics of the small intestine, brain, kidney, liver and placenta. (en)
Title
  • Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics
  • Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics (en)
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  • Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics
  • Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics (en)
skos:notation
  • RIV/00216208:11160/10:00300602!RIV11-MSM-11160___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, V
http://linked.open...iv/cisloPeriodika
  • 596
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 258512
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11160/10:00300602
http://linked.open...riv/jazykVysledku
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  • P-glycoprotein; expression; function; localization; normal tissues; pharmacokinetics; drug absorption; drug distribution; drug excretion (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [42AAF486249F]
http://linked.open...i/riv/nazevZdroje
  • Methods in Molecular Biology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 596
http://linked.open...iv/tvurceVysledku
  • Mičuda, Stanislav
  • Pávek, Petr
  • Čečková, Martina
  • Štaud, František
issn
  • 1940-6029
number of pages
http://localhost/t...ganizacniJednotka
  • 11160
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