About: Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We demonstrate that benzodiazepines medazepam and midazolam are activators of PXR nuclear receptor in transcriptional regulation of CYP3A4 as suggested in experiments on primary human hepatocytes and in HepG2 cells. We demonstrate that benzodiazepines medazepam and midazolam are activators of PXR nuclear receptor in transcriptional regulation of CYP3A4 as suggested in experiments on primary human hepatocytes and in HepG2 cells. (en)
Title	Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines (en)
skos:prefLabel	Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines (en)
skos:notation	RIV/00216208:11160/10:00300596!RIV11-GA0-11160___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GA303/07/0128), P(GAP304/10/0149), P(GP305/08/P089), S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pávek, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	248603
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/10:00300596
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human hepatocytes; cytochrome P450; benzodiazepines; enzyme induction (en)
http://linked.open.../riv/klicoveSlovo	human hepatocytes benzodiazepines cytochrome P450 enzyme induction
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[8B2B8523092D]
http://linked.open...i/riv/nazevZdroje	Toxicology Letters
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on tissue-specific aspects of transcriptional regulation of selected P-450 enzymes and drug transporters. Generation of hepatocyte-derived cellular models for preclinical testing of drugs The role of MAP kinases in cellular signalling of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	193
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk Pávek, Petr Vrzal, Radim Kubešová, Kateřina
http://linked.open...ain/vavai/riv/wos	000276175200009
issn	0378-4274
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software