About: Enzyme stereospecificity as a powerful tool in searching for new enzymes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chirality is an important aspect of drug metabolism. Biotransformation of chiral and prochiral drugs is more complex because diverse formation of metabolite enantiomers. Drugs are often substrates for multiple enzymes and each can metabolize the drug with various stereospecifities. Differences in enzyme stereospecificity are possible to utilize in searching for new enzymes. Chirality is an important aspect of drug metabolism. Biotransformation of chiral and prochiral drugs is more complex because diverse formation of metabolite enantiomers. Drugs are often substrates for multiple enzymes and each can metabolize the drug with various stereospecifities. Differences in enzyme stereospecificity are possible to utilize in searching for new enzymes. (en)
Title	Enzyme stereospecificity as a powerful tool in searching for new enzymes Enzyme stereospecificity as a powerful tool in searching for new enzymes (en)
skos:prefLabel	Enzyme stereospecificity as a powerful tool in searching for new enzymes Enzyme stereospecificity as a powerful tool in searching for new enzymes (en)
skos:notation	RIV/00216208:11160/10:00300581!RIV11-GA0-11160___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA303/07/0994), S, Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Skarka, Adam Wsól, Vladimír Škarydová, Lucie Solich, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	257355
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/10:00300581
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biotransformation; chiral; drugs; metabolism; prochiral; reduction; xenobiotics (en)
http://linked.open.../riv/klicoveSlovo	xenobiotics chiral metabolism reduction drugs prochiral biotransformation
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[06566C13515D]
http://linked.open...i/riv/nazevZdroje	Current Drug Metabolism
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Targeting the novel human microsomal reductases causing resistance in cancer chemotherapy.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Solich, Petr Skarka, Adam Wsól, Vladimír Škarydová, Lucie
http://linked.open...ain/vavai/riv/wos	000280130100007
http://linked.open...n/vavai/riv/zamer	Research of new drug structures
issn	1389-2002
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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