About: Reactivation of human brain homogenate cholinesterases inhibited by tabun using newly developed oximes K117 and K127

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About: Reactivation of human brain homogenate cholinesterases inhibited by tabun using newly developed oximes K117 and K127 Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime and trimedoxime were chosen as standard reference reactivators. Human tissue was used, as that was closer on the real treatment of human beings. As a result, oxime K127 was found as the best tested reactivator according to the constant k(r), characterizing the overall reactivation process. On the contrary, the maximal reactivation ability expressed as percentage of reactivation was the best for trimedoxime. This differences were caused as a result of using the enzyme from different species. Due to this, experiments on human tissue should be conducted after in vitro and in vivo tests on animals to eliminate such important failures of promising oximes. Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime and trimedoxime were chosen as standard reference reactivators. Human tissue was used, as that was closer on the real treatment of human beings. As a result, oxime K127 was found as the best tested reactivator according to the constant k(r), characterizing the overall reactivation process. On the contrary, the maximal reactivation ability expressed as percentage of reactivation was the best for trimedoxime. This differences were caused as a result of using the enzyme from different species. Due to this, experiments on human tissue should be conducted after in vitro and in vivo tests on animals to eliminate such important failures of promising oximes. (en)
Title	Reactivation of human brain homogenate cholinesterases inhibited by tabun using newly developed oximes K117 and K127 Reactivation of human brain homogenate cholinesterases inhibited by tabun using newly developed oximes K117 and K127 (en)
skos:prefLabel	Reactivation of human brain homogenate cholinesterases inhibited by tabun using newly developed oximes K117 and K127 Reactivation of human brain homogenate cholinesterases inhibited by tabun using newly developed oximes K117 and K127 (en)
skos:notation	RIV/00216208:11160/09:00300505!RIV11-MSM-11160___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ME 865), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Musilová, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	338202
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/09:00300505
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxime; reactivator; cholinesterase; nerve agent; tabun; K-oximes; trimedoxime; pralidoxime (en)
http://linked.open.../riv/klicoveSlovo	pralidoxime cholinesterase tabun trimedoxime nerve agent oxime reactivator K-oximes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3CBFCE38E439]
http://linked.open...i/riv/nazevZdroje	Basic & Clinical Pharmacology & Toxicology
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20865
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Hrabinová, Martina Kuča, Kamil Musílek, Kamil Novotný, Ladislav Pohanka, Miroslav Žďárová Karasová, Jana Jun, Daniel Musilová, Lucie Soukup, Ondřej Jung, Young Sik
http://linked.open...ain/vavai/riv/wos	000268960200009
issn	1742-7835
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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