About: Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin     Goto   Sponge   NotDistinct   Permalink

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Description
  • In this study it was purified a new membrane-bound carbonyl reductase from human liver microsomes that takes part to biotransformation of anticancer drug oracin. Determined kinetic parameters for this enzyme and oracin are several times better than the same parameters for 11beta-HSD1 that is currently only one well-known microsomal carbonyl reductase contributing to metabolism of xenobiotics.
  • In this study it was purified a new membrane-bound carbonyl reductase from human liver microsomes that takes part to biotransformation of anticancer drug oracin. Determined kinetic parameters for this enzyme and oracin are several times better than the same parameters for 11beta-HSD1 that is currently only one well-known microsomal carbonyl reductase contributing to metabolism of xenobiotics. (en)
Title
  • Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin
  • Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin (en)
skos:prefLabel
  • Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin
  • Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin (en)
skos:notation
  • RIV/00216208:11160/09:00210081!RIV10-GA0-11160___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA303/07/0994), S
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 332738
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11160/09:00210081
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • purification; microsomes; carbonyl reduction; oracin; enzyme kinetics (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [D6643B4B6E7D]
http://linked.open...i/riv/nazevZdroje
  • Toxicology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 264
http://linked.open...iv/tvurceVysledku
  • Skarka, Adam
  • Wsól, Vladimír
  • Škarydová, Lucie
  • Maser, Edmund
  • Novotná, Romana
  • Živná, Lucie
  • Martin, Hans-Joerg
http://linked.open...ain/vavai/riv/wos
  • 000270531400007
issn
  • 0300-483X
number of pages
http://localhost/t...ganizacniJednotka
  • 11160
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