About: Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase

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About: Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203); the known reactivators (pralidoxime, HI-6, obidoxime, K075, K203) and the new compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203); the known reactivators (pralidoxime, HI-6, obidoxime, K075, K203) and the new compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE (en) Bylo vyvinuto patnáct nových monooximových reaktivátorů acetylcholinesterázy s (E)-but-2-enovým můstkem ve snaze rozšířit vlastnosti K-oximu (E)-1-(4-karbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-en dibromidu (K203); známé reaktivátory (pralidoxime, HI-6, obidoxime, K075, K203) a nové sloučeniny byly testovány in vitro na modelu tabunem a paraxonem inhibované AChE (cs)
Title	Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase (en) Monooximové reaktivátory acetylcholinesterasy s (E)-but-2-enovým můstkem - Příprava a reaktivace tabunem a paraoxonem inhibované acetylcholinesterasy (cs)
skos:prefLabel	Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase (en) Monooximové reaktivátory acetylcholinesterasy s (E)-but-2-enovým můstkem - Příprava a reaktivace tabunem a paraoxonem inhibované acetylcholinesterasy (cs)
skos:notation	RIV/00216208:11160/07:00006690!RIV08-MO0-11160___
http://linked.open.../vavai/riv/strany	6733;6741
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(OPUOFVZ200603), V
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	435034
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/07:00006690
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Monooxime; reactivators; acetylcholinesterase; -but-2-ene; linker; Preparation; reactivation; tabun-; paraoxon-inhibited; acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo	Preparation linker Monooxime paraoxon-inhibited tabun- acetylcholinesterase reactivation reactivators -but-2-ene
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A1A3F4E024CC]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Musílek, Kamil
issn	0968-0896
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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