| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - A new strategy for the synthesis of trans-and cis + trans-3,4,5-trisubstituted isoxazolines from allyl compounds of QCH(2)CH=CH2 type (Q = PhO, 2,2'-bithiophen-5-yl, BuO, Me3CS, PhN(COMe) and others) has been developed. The dipolarophiles are prepared via: a) Ru-carbene catalysed metathesis of Qallyl; b) catalytic isomerization followed by Ru-carbene mediated metathesis; c) Ru-carbene catalysed metathesis followed by isomerization. 1,3-dipolar cycloaddition of nitrile oxide to dipolarophiles obtained via route a), b) or c), including high pressure activated reactions leads to 3,4,5-trisubstituted isoxazolines. Quantitative E-stereoselective homometathesis of some QCH(2)CH=CH2 to (E)-QCH(2)CH=CHCH(2)Q and new highly effective ruthenium and basic catalytic systems for the isomerization of allyl compounds have also been presented. Moreover, easily available (Z)-XCH2CH=CHCH2X allyl compounds were used for the synthesis of cis-3,4,5-trisubstituted isoxazolines. It has been proved by in vitro tests that some of the isoxazolines show interesting antifungal activity comparable to that of fluconazole.
- A new strategy for the synthesis of trans-and cis + trans-3,4,5-trisubstituted isoxazolines from allyl compounds of QCH(2)CH=CH2 type (Q = PhO, 2,2'-bithiophen-5-yl, BuO, Me3CS, PhN(COMe) and others) has been developed. The dipolarophiles are prepared via: a) Ru-carbene catalysed metathesis of Qallyl; b) catalytic isomerization followed by Ru-carbene mediated metathesis; c) Ru-carbene catalysed metathesis followed by isomerization. 1,3-dipolar cycloaddition of nitrile oxide to dipolarophiles obtained via route a), b) or c), including high pressure activated reactions leads to 3,4,5-trisubstituted isoxazolines. Quantitative E-stereoselective homometathesis of some QCH(2)CH=CH2 to (E)-QCH(2)CH=CHCH(2)Q and new highly effective ruthenium and basic catalytic systems for the isomerization of allyl compounds have also been presented. Moreover, easily available (Z)-XCH2CH=CHCH2X allyl compounds were used for the synthesis of cis-3,4,5-trisubstituted isoxazolines. It has been proved by in vitro tests that some of the isoxazolines show interesting antifungal activity comparable to that of fluconazole. (en)
|
| Title
| - New Strategy for the Synthesis of 3,4,5-trisubstituted Isoxazolines from Allyl Compounds
- New Strategy for the Synthesis of 3,4,5-trisubstituted Isoxazolines from Allyl Compounds (en)
|
| skos:prefLabel
| - New Strategy for the Synthesis of 3,4,5-trisubstituted Isoxazolines from Allyl Compounds
- New Strategy for the Synthesis of 3,4,5-trisubstituted Isoxazolines from Allyl Compounds (en)
|
| skos:notation
| - RIV/00216208:11150/14:10287516!RIV15-MSM-11150___
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/14:10287516
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Regioselectivity; Metathesis; Isoxazolines; Isomerization; Homogeneous catalysis; High-pressure chemistry; Antifungal agents; 3-Dipolar Cycloaddition; 1 (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - AE - Stát Spojené arabské emiráty
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Current Organic Chemistry
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Jampílek, Josef
- Vejsová, Marcela
- Musiol, Robert
- Polanski, Jaroslaw
- Danikiewicz, Witold
- Filapek, Michal
- Kania, Magdalena
- Krompiec, Stanislaw
- Malarz, Joanna
- Malecki, Jan G.
- Marcol, Beata
- Paluch, Marian
- Pawlus, Sebastian
- Penkala, Mateusz
- Pietraszuk, Cezary
- Powala, Beata
- Rogalski, Szymon
|
| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)