About: Multipotent mesenchymal stromal cells in otorhinolaryngology

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0306987714001352
Description	Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy. They regenerate through self-renewal, differentiational capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSCs applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. Current evidence of MSCs treatment efficacy in otorhinolaryngology is based on animal models. The true impact on clinical treatment will not be known until clinical studies prove functional outcomes in human medicine. Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy. They regenerate through self-renewal, differentiational capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSCs applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. Current evidence of MSCs treatment efficacy in otorhinolaryngology is based on animal models. The true impact on clinical treatment will not be known until clinical studies prove functional outcomes in human medicine. (en)
Title	Multipotent mesenchymal stromal cells in otorhinolaryngology Multipotent mesenchymal stromal cells in otorhinolaryngology (en)
skos:prefLabel	Multipotent mesenchymal stromal cells in otorhinolaryngology Multipotent mesenchymal stromal cells in otorhinolaryngology (en)
skos:notation	RIV/00216208:11150/14:10283783!RIV15-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Školoudík, Lukáš Kalfeřt, David Filip, Stanislav Chrobok, Viktor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	31104
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/14:10283783
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cartilage replacement; bone replacement; otorhinolaryngology; mesenchymal stromal cells (en)
http://linked.open.../riv/klicoveSlovo	cartilage replacement mesenchymal stromal cells otorhinolaryngology bone replacement
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1341528ECCBB]
http://linked.open...i/riv/nazevZdroje	Medical Hypotheses
http://linked.open...in/vavai/riv/obor	FF
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Chrobok, Viktor Filip, Stanislav Kalfeřt, David Školoudík, Lukáš Kočí, Zuzana
http://linked.open...ain/vavai/riv/wos	000336704200028
issn	0306-9877
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mehy.2014.03.022
http://localhost/t...ganizacniJednotka	11150

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