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rdf:type
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Description
| - Aim: The aim of the present study was to investigate tumor-infiltrating leukocytes in patients with endometrial carcinoma. Patients and Methods: Cluster of differentiation (CD) 3(+), CD8(+) and C20(+) tumor-infiltrating lymphocytes (TILs) and CD68(+) tumor-associated macrophages (TAMs) were evaluated retrospectively by immunohistochemistry in tumor specimen from 124 patients with endometrial carcinoma. Results: A significant decrease of CD3(+) TILs and an increase of CD68(+) TAM count was associated with higher tumor stage. In patients with earlystage, high-risk tumors, low intraepithelial CD3(+) TIL counts were associated with significantly inferior survival. In multivariate analysis of patients with early-stage tumors, intraepithelial CD3(+) TIL counts were an independent predictor of survival. Conclusion: In patients with endometrial carcinoma a decrease of intraepithelial CD3(+) TIL counts is associated with advanced stage and high risk group. Intraepithelial CD3(+) TIL counts are an independent predictor of survival in patients with early tumors.
- Aim: The aim of the present study was to investigate tumor-infiltrating leukocytes in patients with endometrial carcinoma. Patients and Methods: Cluster of differentiation (CD) 3(+), CD8(+) and C20(+) tumor-infiltrating lymphocytes (TILs) and CD68(+) tumor-associated macrophages (TAMs) were evaluated retrospectively by immunohistochemistry in tumor specimen from 124 patients with endometrial carcinoma. Results: A significant decrease of CD3(+) TILs and an increase of CD68(+) TAM count was associated with higher tumor stage. In patients with earlystage, high-risk tumors, low intraepithelial CD3(+) TIL counts were associated with significantly inferior survival. In multivariate analysis of patients with early-stage tumors, intraepithelial CD3(+) TIL counts were an independent predictor of survival. Conclusion: In patients with endometrial carcinoma a decrease of intraepithelial CD3(+) TIL counts is associated with advanced stage and high risk group. Intraepithelial CD3(+) TIL counts are an independent predictor of survival in patients with early tumors. (en)
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Title
| - Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma
- Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma (en)
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skos:prefLabel
| - Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma
- Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma (en)
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skos:notation
| - RIV/00216208:11150/14:10283483!RIV15-MSM-11150___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(ED0030/01/01), P(LM2010004)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/14:10283483
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - tumor-infiltrating lymphocytes; tumor-associated macrophages; endometrial carcinoma; Biomarkers (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kalábová, Hana
- Melichar, Bohuslav
- Špaček, Jiří
- Tomšová, Markéta
- Zoul, Zdeněk
- Čermáková, Petra
- Doležel, Martin
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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