About: Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma

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About: Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aim: The aim of the present study was to investigate tumor-infiltrating leukocytes in patients with endometrial carcinoma. Patients and Methods: Cluster of differentiation (CD) 3(+), CD8(+) and C20(+) tumor-infiltrating lymphocytes (TILs) and CD68(+) tumor-associated macrophages (TAMs) were evaluated retrospectively by immunohistochemistry in tumor specimen from 124 patients with endometrial carcinoma. Results: A significant decrease of CD3(+) TILs and an increase of CD68(+) TAM count was associated with higher tumor stage. In patients with earlystage, high-risk tumors, low intraepithelial CD3(+) TIL counts were associated with significantly inferior survival. In multivariate analysis of patients with early-stage tumors, intraepithelial CD3(+) TIL counts were an independent predictor of survival. Conclusion: In patients with endometrial carcinoma a decrease of intraepithelial CD3(+) TIL counts is associated with advanced stage and high risk group. Intraepithelial CD3(+) TIL counts are an independent predictor of survival in patients with early tumors. Aim: The aim of the present study was to investigate tumor-infiltrating leukocytes in patients with endometrial carcinoma. Patients and Methods: Cluster of differentiation (CD) 3(+), CD8(+) and C20(+) tumor-infiltrating lymphocytes (TILs) and CD68(+) tumor-associated macrophages (TAMs) were evaluated retrospectively by immunohistochemistry in tumor specimen from 124 patients with endometrial carcinoma. Results: A significant decrease of CD3(+) TILs and an increase of CD68(+) TAM count was associated with higher tumor stage. In patients with earlystage, high-risk tumors, low intraepithelial CD3(+) TIL counts were associated with significantly inferior survival. In multivariate analysis of patients with early-stage tumors, intraepithelial CD3(+) TIL counts were an independent predictor of survival. Conclusion: In patients with endometrial carcinoma a decrease of intraepithelial CD3(+) TIL counts is associated with advanced stage and high risk group. Intraepithelial CD3(+) TIL counts are an independent predictor of survival in patients with early tumors. (en)
Title	Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma (en)
skos:prefLabel	Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma (en)
skos:notation	RIV/00216208:11150/14:10283483!RIV15-MSM-11150___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED0030/01/01), P(LM2010004)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Melichar, Bohuslav Špaček, Jiří Hájková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	40103
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/14:10283483
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tumor-infiltrating lymphocytes; tumor-associated macrophages; endometrial carcinoma; Biomarkers (en)
http://linked.open.../riv/klicoveSlovo	tumor-infiltrating lymphocytes endometrial carcinoma Biomarkers tumor-associated macrophages
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[B31A5DD55BDE]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	BBMRI_CZ in the building of the Czech part of a large distributed research infrastructure of pan-European importance: the creation and operation of the network of banks of biological material for biomedical research Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Kalábová, Hana Melichar, Bohuslav Špaček, Jiří Tomšová, Markéta Zoul, Zdeněk Čermáková, Petra Doležel, Martin
http://linked.open...ain/vavai/riv/wos	000343139500041
issn	0250-7005
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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