About: Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium

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About: Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1515/cclm-2013-0162
Description	Background: Epigenetic changes are considered to be a frequent event during tumor development. Various methylation changes have been identified and show promise as potential cancer biomarkers. The aim of this study was to investigate promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Methods: To search for promoter methylation of GATA4 and TP53 genes we used methylation-specific PCR (MSP) to compare the methylation status of 54 patients with endometrioid carcinoma of endometrium and 18 patients with normal endometrial tissue. Results: In our study MSP revealed GATA4 promoter methylation in 44 of 54 in the carcinoma group (81.5%), and in none of the control group. No methylation was observed in TP53 gene. Conclusions: In conclusion, our study showed that there is significantly higher methylation in GATA4 gene in the endometrial cancer group compared with samples of nonneoplastic endometrium. The finding suggests the importance of hypermethylation of this gene in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies for endometrial cancer based on epigenetic changes. Background: Epigenetic changes are considered to be a frequent event during tumor development. Various methylation changes have been identified and show promise as potential cancer biomarkers. The aim of this study was to investigate promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Methods: To search for promoter methylation of GATA4 and TP53 genes we used methylation-specific PCR (MSP) to compare the methylation status of 54 patients with endometrioid carcinoma of endometrium and 18 patients with normal endometrial tissue. Results: In our study MSP revealed GATA4 promoter methylation in 44 of 54 in the carcinoma group (81.5%), and in none of the control group. No methylation was observed in TP53 gene. Conclusions: In conclusion, our study showed that there is significantly higher methylation in GATA4 gene in the endometrial cancer group compared with samples of nonneoplastic endometrium. The finding suggests the importance of hypermethylation of this gene in endometrial carcinogenesis and could have implications for future diagnostic and therapeutic strategies for endometrial cancer based on epigenetic changes. (en)
Title	Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium (en)
skos:prefLabel	Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium (en)
skos:notation	RIV/00216208:11150/14:10282721!RIV15-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Palička, Vladimír Laco, Jan Špaček, Jiří Dvořáková, Eva Kos, Špela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	20927
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/14:10282721
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	methylation; gene TP53; GATA4 transcription factor; epigenomics; endometrial neoplasms (en)
http://linked.open.../riv/klicoveSlovo	methylation epigenomics gene TP53 GATA4 transcription factor endometrial neoplasms
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[77F5E034D26D]
http://linked.open...i/riv/nazevZdroje	Clinical Chemistry and Laboratory Medicine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Chmelařová, Marcela Laco, Jan Palička, Vladimír Špaček, Jiří Dvořáková, Eva Hrochová, Kateřina Ruszová, Ema Kos, Špela
http://linked.open...ain/vavai/riv/wos	000340786100026
issn	1434-6621
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1515/cclm-2013-0162
http://localhost/t...ganizacniJednotka	11150

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