About: Protective Effect of Captopril, Olmesartan, Melatonin and Compound 21 on Doxorubicin-Induced Nephrotoxicity in Rats

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About: Protective Effect of Captopril, Olmesartan, Melatonin and Compound 21 on Doxorubicin-Induced Nephrotoxicity in Rats Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomed.cas.cz/physiolres/pdf/62/62_S181.pdf
Description	The aim of this study was to compare the effect of melatonin and angiotensin II type 2 receptor agonist compound 21 (C21) to angiotensin converting enzyme inhibitor captopril and angiotensin II type 1 receptor blocker olmesartan on animal model of doxorubicin nephrotoxicity. Six groups of Wistar rats were treated for four weeks. The first group served as a control. The remaining groups were injected with a single dose of doxorubicin (5 mg/kg i.v.) at the same day as administration of either vehicle or captopril (100 mg/kg/day) or olmesartan (10 mg/kg/day) or melatonin (10 mg/kg/day) or C21 (0.3 mg/kg/day) was initiated. All four substances significantly diminished the level of oxidative burden and prevented the reduction of glomerular density. We conclude that captopril, olmesartan, melatonin and C21 exerted a similar level of renoprotective effects in doxorubicin-induced nephrotoxicity. The aim of this study was to compare the effect of melatonin and angiotensin II type 2 receptor agonist compound 21 (C21) to angiotensin converting enzyme inhibitor captopril and angiotensin II type 1 receptor blocker olmesartan on animal model of doxorubicin nephrotoxicity. Six groups of Wistar rats were treated for four weeks. The first group served as a control. The remaining groups were injected with a single dose of doxorubicin (5 mg/kg i.v.) at the same day as administration of either vehicle or captopril (100 mg/kg/day) or olmesartan (10 mg/kg/day) or melatonin (10 mg/kg/day) or C21 (0.3 mg/kg/day) was initiated. All four substances significantly diminished the level of oxidative burden and prevented the reduction of glomerular density. We conclude that captopril, olmesartan, melatonin and C21 exerted a similar level of renoprotective effects in doxorubicin-induced nephrotoxicity. (en)
Title	Protective Effect of Captopril, Olmesartan, Melatonin and Compound 21 on Doxorubicin-Induced Nephrotoxicity in Rats Protective Effect of Captopril, Olmesartan, Melatonin and Compound 21 on Doxorubicin-Induced Nephrotoxicity in Rats (en)
skos:prefLabel	Protective Effect of Captopril, Olmesartan, Melatonin and Compound 21 on Doxorubicin-Induced Nephrotoxicity in Rats Protective Effect of Captopril, Olmesartan, Melatonin and Compound 21 on Doxorubicin-Induced Nephrotoxicity in Rats (en)
skos:notation	RIV/00216208:11150/13:10190735!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Adamcová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	100518
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10190735
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxidative stress; C21 substance; melatonin; olmesartan; caproptil; doxorubiicin; Nephroprotection (en)
http://linked.open.../riv/klicoveSlovo	C21 substance Nephroprotection caproptil doxorubiicin olmesartan melatonin oxidative stress
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D33A18D8C159]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Celec, Peter Aziriová, Silvia Hrenák, Jaroslav Krajčírovičová, Kristina Paulis, Ludovít Šimko, Fedor Arendašová, Karina. Bárta, Andrej Kamodyová, Natalia Rajkovičová, Romana Repová, Kristina
http://linked.open...ain/vavai/riv/wos	000328901900020
issn	0862-8408
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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