About: Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension

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About: Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomed.cas.cz/physiolres/pdf/62/62_S135.pdf
Description	Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or captopril can prevent these potential alterations. In a six-week experiment, Wistar rats were divided into 4 groups: controls, rats exposed to continuous light (LC), LC + captopril (100 mg/kg/24 h) and LC + melatonin (10 mg/kg/24 h). We conclude that in continuous light-induced hypertension, administration of melatonin, along with SBP reduction, decreases collagen I and III concentration in the aorta. It is suggested that antifibrotic effect of melatonin may reduce the stiffness of the aorta and small arteries and beneficially influence the peripheral vascular resistance. Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or captopril can prevent these potential alterations. In a six-week experiment, Wistar rats were divided into 4 groups: controls, rats exposed to continuous light (LC), LC + captopril (100 mg/kg/24 h) and LC + melatonin (10 mg/kg/24 h). We conclude that in continuous light-induced hypertension, administration of melatonin, along with SBP reduction, decreases collagen I and III concentration in the aorta. It is suggested that antifibrotic effect of melatonin may reduce the stiffness of the aorta and small arteries and beneficially influence the peripheral vascular resistance. (en)
Title	Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension (en)
skos:prefLabel	Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension (en)
skos:notation	RIV/00216208:11150/13:10190725!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Adamcová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	71394
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10190725
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Collagen I and III; Captopril; Melatonin; Fibrosis; Hypertension; Continuous light (en)
http://linked.open.../riv/klicoveSlovo	Captopril Collagen I and III Continuous light Fibrosis Melatonin Hypertension
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[9434CA109482]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Adamcová, Michaela Aziriová, Silvia Hrenák, Jaroslav Krajčírovičová, Kristina Paulis, Ludovít Repová-Bednarová, Kristina Šimko, Fedor
http://linked.open...ain/vavai/riv/wos	000328901900015
issn	0862-8408
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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