About: Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells

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About: Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Colorectal carcinoma (CRC) continues to be a major problem in developed countries, and successful preventive strategies concerning this malignancy are still missing. Sodium selenite has emerged as a potential chemopreventive agent due to a number of specials effects which produce colon cancer cells, regardless of their status. Selenite has been able to decrease cell proliferation and induce cytotoxicity by several mechanisms. These include direct inhibition of several molecular targets, signaling pathways (p53-dependent, mTOR, p38, JNK), or subcellular compartments (mitochondria), as well as activation of apoptosis and autophagy. Our data combined with results of studies conducted by other reserarch groups demonstrate a close connection between selenite-induced oxidative stress and apoptosis. In addition, the concurrent existence of autophagy and apoptosis in selenite-treated cells, their mutual relationship, and diverse regulatory patterns upon differing p53 status of cells suggest a multilevel regulation of both processes which warrants future studies. Colorectal carcinoma (CRC) continues to be a major problem in developed countries, and successful preventive strategies concerning this malignancy are still missing. Sodium selenite has emerged as a potential chemopreventive agent due to a number of specials effects which produce colon cancer cells, regardless of their status. Selenite has been able to decrease cell proliferation and induce cytotoxicity by several mechanisms. These include direct inhibition of several molecular targets, signaling pathways (p53-dependent, mTOR, p38, JNK), or subcellular compartments (mitochondria), as well as activation of apoptosis and autophagy. Our data combined with results of studies conducted by other reserarch groups demonstrate a close connection between selenite-induced oxidative stress and apoptosis. In addition, the concurrent existence of autophagy and apoptosis in selenite-treated cells, their mutual relationship, and diverse regulatory patterns upon differing p53 status of cells suggest a multilevel regulation of both processes which warrants future studies. (en)
Title	Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells (en)
skos:prefLabel	Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells (en)
skos:notation	RIV/00216208:11150/13:10173576!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Rudolf, Emil
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	104538
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10173576
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colon cancer; autophagy; apoptosis; selenite (en)
http://linked.open.../riv/klicoveSlovo	selenite apoptosis colon cancer autophagy
http://linked.open...ontrolniKodProRIV	[1BA0C81AC929]
http://linked.open...i/riv/mistoVydani	Amsterdam
http://linked.open...i/riv/nazevZdroje	Autophagy: cancer, other pathologies, inflammation, immunity infection, and aging. Volume 1, Molecular Mechanisms
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	329 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Rudolf, Emil
number of pages	13 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Elsevier
https://schema.org/isbn	978-0-12-405530-8
http://localhost/t...ganizacniJednotka	11150

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