About: The effect of levetiracetam on rat bone mass, structure and metabolism

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0920121113002179
Description	Epilepsy is a condition affecting 0,5 - 1% of the population in developed countries. Antiepileptic drugs can adversely affect bone health. We report our findings in orchidectomised rats fed on levetiracetam-enriched diet for 12 weeks concerning the impact of levetiracetam (LEV) on bone markers, bone mineral density (BMD) and biomechanical properties. Compared to the control group we found lower fat mass, lower BMD in the area of the left femur, lower BMC (bone mineral content) in both femur a reduced OPG (osteoprotegerin), and an increased concentration CTX-I (corboxy-terminal cross-linking telopeptide of type I collagen) of borderline statistical significance. Our results suggest that in the ORX-rat model LEV may affect bone mass of the femoral diaphysis (cortical bone) and suggest that LEV may suppress bone turnover. We may assume that the reduction in serum OPG levels could be explained by the inhibition of osteoblast activity. But further studies in animals and humans will be needed to confirm these findings. Epilepsy is a condition affecting 0,5 - 1% of the population in developed countries. Antiepileptic drugs can adversely affect bone health. We report our findings in orchidectomised rats fed on levetiracetam-enriched diet for 12 weeks concerning the impact of levetiracetam (LEV) on bone markers, bone mineral density (BMD) and biomechanical properties. Compared to the control group we found lower fat mass, lower BMD in the area of the left femur, lower BMC (bone mineral content) in both femur a reduced OPG (osteoprotegerin), and an increased concentration CTX-I (corboxy-terminal cross-linking telopeptide of type I collagen) of borderline statistical significance. Our results suggest that in the ORX-rat model LEV may affect bone mass of the femoral diaphysis (cortical bone) and suggest that LEV may suppress bone turnover. We may assume that the reduction in serum OPG levels could be explained by the inhibition of osteoblast activity. But further studies in animals and humans will be needed to confirm these findings. (en)
Title	The effect of levetiracetam on rat bone mass, structure and metabolism The effect of levetiracetam on rat bone mass, structure and metabolism (en)
skos:prefLabel	The effect of levetiracetam on rat bone mass, structure and metabolism The effect of levetiracetam on rat bone mass, structure and metabolism (en)
skos:notation	RIV/00216208:11150/13:10173388!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Palička, Vladimír Hubená, Soňa Živný, Pavel Živná, Helena Gradošová, Iveta Šimko, Julius
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	71590
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10173388
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bone markers; bone mineral density; levetiracetam; Antiepileptic drugs (en)
http://linked.open.../riv/klicoveSlovo	Antiepileptic drugs levetiracetam bone mineral density bone markers
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[8BE245D27DA3]
http://linked.open...i/riv/nazevZdroje	Epilepsy Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	107
http://linked.open...iv/tvurceVysledku	Gradošová, Iveta Palička, Vladimír Živná, Helena Živný, Pavel Fekete, Soňa Maláková, Jana Šimko, Julius
http://linked.open...ain/vavai/riv/wos	000328524800006
issn	0920-1211
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.eplepsyres.2013.08.012
http://localhost/t...ganizacniJednotka	11150

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