About: Whipple's Disease: Our Own Experience and Review of the Literature

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1155/2013/478349
Description	Whipple's disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. Possible neurologic symptoms (up to 20%) might be associated with worse prognosis. Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material. Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases. This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre. Patients were treated using i.v. penicillin G or amoxicillin-clavulanic acid + i.v. gentamicin for two weeks, followed by p.o. doxycycline (100 mg per day) plus p.o. salazopyrine (3 g per day) for 1 year. Full remission was achieved in all our patients. Whipple's disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. Possible neurologic symptoms (up to 20%) might be associated with worse prognosis. Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material. Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases. This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre. Patients were treated using i.v. penicillin G or amoxicillin-clavulanic acid + i.v. gentamicin for two weeks, followed by p.o. doxycycline (100 mg per day) plus p.o. salazopyrine (3 g per day) for 1 year. Full remission was achieved in all our patients. (en)
Title	Whipple's Disease: Our Own Experience and Review of the Literature Whipple's Disease: Our Own Experience and Review of the Literature (en)
skos:prefLabel	Whipple's Disease: Our Own Experience and Review of the Literature Whipple's Disease: Our Own Experience and Review of the Literature (en)
skos:notation	RIV/00216208:11150/13:10139017!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kopáčová, Marcela Tachecí, Ilja Rejchrt, Stanislav Bureš, Jan Douda, Tomáš Tomš, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	117326
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10139017
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bacterium; whippelii; endoscopy; prevalence; ceftriaxone; patient; infection; involvement; antibiotic susceptibility; tropheryma-whipplei (en)
http://linked.open.../riv/klicoveSlovo	endoscopy - digestive system - surgery - colorectal carcinoma infection patient prevalence ceftriaxone antibiotic susceptibility tropheryma-whipplei whippelii involvement bacterium
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C6795F65DB47]
http://linked.open...i/riv/nazevZdroje	Gastroenterology Research and Practice
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	Neuveden
http://linked.open...iv/tvurceVysledku	Bureš, Jan Bártová, Jolana Kopáčová, Marcela Rejchrt, Stanislav Tachecí, Ilja Douda, Tomáš Tomš, Jan
http://linked.open...ain/vavai/riv/wos	000321353600001
issn	1687-6121
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2013/478349
http://localhost/t...ganizacniJednotka	11150

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