About: Vanadocene and niobocene dihalides containing electron-withdrawing substituents in the cyclopentadienyl rings: Synthesis, characterization and cytotoxicity

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About: Vanadocene and niobocene dihalides containing electron-withdrawing substituents in the cyclopentadienyl rings: Synthesis, characterization and cytotoxicity Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0020169313001515
Description	The first example of the group V metallocene dihalides substituted in the cyclopentadienyl rings with electron-withdrawing substituents is reported. This study includes synthesis and spectroscopic characterization of the series of vanadocene and niobocene compounds functionalized in the cyclopentadienyl rings with the ester groups. Structures of (eta(5)-C5H4COOPh)(2)VCl2, (eta(5)-C5H4COOMe)(2)VBr2 center dot CH2Cl2, (eta(5)-C5H4-COOPh)(2)NbCl2, (eta(5)-C5H4COOMe)(2)NbBr2 and (eta(5)-C5H4COOEt)(2)NbBr2 were determined by X-ray diffraction analysis. Cytotoxic activity toward human leukemia cells MOLT-4 was established in vitro for all newly prepared metallocene compounds. The first example of the group V metallocene dihalides substituted in the cyclopentadienyl rings with electron-withdrawing substituents is reported. This study includes synthesis and spectroscopic characterization of the series of vanadocene and niobocene compounds functionalized in the cyclopentadienyl rings with the ester groups. Structures of (eta(5)-C5H4COOPh)(2)VCl2, (eta(5)-C5H4COOMe)(2)VBr2 center dot CH2Cl2, (eta(5)-C5H4-COOPh)(2)NbCl2, (eta(5)-C5H4COOMe)(2)NbBr2 and (eta(5)-C5H4COOEt)(2)NbBr2 were determined by X-ray diffraction analysis. Cytotoxic activity toward human leukemia cells MOLT-4 was established in vitro for all newly prepared metallocene compounds. (en)
Title	Vanadocene and niobocene dihalides containing electron-withdrawing substituents in the cyclopentadienyl rings: Synthesis, characterization and cytotoxicity Vanadocene and niobocene dihalides containing electron-withdrawing substituents in the cyclopentadienyl rings: Synthesis, characterization and cytotoxicity (en)
skos:prefLabel	Vanadocene and niobocene dihalides containing electron-withdrawing substituents in the cyclopentadienyl rings: Synthesis, characterization and cytotoxicity Vanadocene and niobocene dihalides containing electron-withdrawing substituents in the cyclopentadienyl rings: Synthesis, characterization and cytotoxicity (en)
skos:notation	RIV/00216208:11150/13:10138863!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	June
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Řezáčová, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	113593
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10138863
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cancer; Platinum; Crystal; Clinical-trial; Molybdenocene complexes; Antitumor-activity; Anticancer drugs; Titanocene dichloride; X-ray-diffraction; Ansa-metallocene derivatives (en)
http://linked.open.../riv/klicoveSlovo	Cancer Ansa-metallocene derivatives Antitumor-activity Clinical-trial Molybdenocene complexes Titanocene dichloride Crystal Anticancer drugs X-ray-diffraction Platinum
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[EF8F8DEDBFB9]
http://linked.open...i/riv/nazevZdroje	Inorganica Chimica Acta
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	402
http://linked.open...iv/tvurceVysledku	Padělková, Zdeňka Vinklárek, Jaromír Řezáčová, Martina Honzíček, Jan Klepalová, Iva Šebestová, Lucie
http://linked.open...ain/vavai/riv/wos	000320651100016
issn	0020-1693
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ica.2013.03.018
http://localhost/t...ganizacniJednotka	11150

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