About: The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells

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About: The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0027510713000158
Description	The role of p38 in irinotecan (CPT-11)-induced damage and cell death in colon cancer cell line SW620 was investigated. We demonstrate that CPT-11 treatment activates p38 in exposed cells, however with concentration dependent dynamics and differing consequences. Higher CPT-11 concentrations induce a massive early but relatively short-lasting p38 activity leading to apoptosis mediated by mitochondria and caspases. Pharmacological or siRNA inhibition of p38 then significantly prevents CPT-11-dependent cell death. Conversely, lower CPT-11 concentrations activate p38 in a delayed, however sustained manner, with apoptosis occurring only in a fraction of cells and in the absence of significant autophagy. Blocking p38 in thus treated cells increases their sensitivity toward CPT-11 and increases cell death. In summary, our results confirm the involvement of p38 in colon cancer cells response to CPT-11 while indicating a varying role of p38 in the final biological response. The role of p38 in irinotecan (CPT-11)-induced damage and cell death in colon cancer cell line SW620 was investigated. We demonstrate that CPT-11 treatment activates p38 in exposed cells, however with concentration dependent dynamics and differing consequences. Higher CPT-11 concentrations induce a massive early but relatively short-lasting p38 activity leading to apoptosis mediated by mitochondria and caspases. Pharmacological or siRNA inhibition of p38 then significantly prevents CPT-11-dependent cell death. Conversely, lower CPT-11 concentrations activate p38 in a delayed, however sustained manner, with apoptosis occurring only in a fraction of cells and in the absence of significant autophagy. Blocking p38 in thus treated cells increases their sensitivity toward CPT-11 and increases cell death. In summary, our results confirm the involvement of p38 in colon cancer cells response to CPT-11 while indicating a varying role of p38 in the final biological response. (en)
Title	The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells (en)
skos:prefLabel	The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells (en)
skos:notation	RIV/00216208:11150/13:10133987!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	January - February
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Rudolf, Kamil John, Stanislav Rudolf, Emil Králová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	103357
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/13:10133987
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p38; Irinotecan; DNA damage; Colon cancer; Apoptosis (en)
http://linked.open.../riv/klicoveSlovo	Irinotecan p38 Apoptosis DNA damage Colon cancer
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[6B64CF3A6F08]
http://linked.open...i/riv/nazevZdroje	Mutation Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	741-742
http://linked.open...iv/tvurceVysledku	Rudolf, Emil Rudolf, Kamil John, Stanislav Králová, Věra
http://linked.open...ain/vavai/riv/wos	000318456400004
issn	0027-5107
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mrfmmm.2013.02.002
http://localhost/t...ganizacniJednotka	11150

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