About: Cannabinoid Receptor 1 Inhibition Causes Seizures During Anesthesia Induction in Experimental Sepsis     Goto   Sponge   NotDistinct   Permalink

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Description
  • We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis. (Anesth Analg 2012;114:1217-9)
  • We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis. (Anesth Analg 2012;114:1217-9) (en)
Title
  • Cannabinoid Receptor 1 Inhibition Causes Seizures During Anesthesia Induction in Experimental Sepsis
  • Cannabinoid Receptor 1 Inhibition Causes Seizures During Anesthesia Induction in Experimental Sepsis (en)
skos:prefLabel
  • Cannabinoid Receptor 1 Inhibition Causes Seizures During Anesthesia Induction in Experimental Sepsis
  • Cannabinoid Receptor 1 Inhibition Causes Seizures During Anesthesia Induction in Experimental Sepsis (en)
skos:notation
  • RIV/00216208:11150/12:10127014!RIV13-MSM-11150___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
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  • 125924
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/12:10127014
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Sepsis; Experimental; Induction; Anesthesia; During; Seizures; Causes; Inhibition; Receptor; Cannabinoid (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [7D152D71B725]
http://linked.open...i/riv/nazevZdroje
  • Anesthesia and Analgesia
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 114
http://linked.open...iv/tvurceVysledku
  • Černý, Vladimír
  • Kelly, Melanie
  • Kianian, Mandana
  • Lehmann, Christian
  • Pavlovic, Dragan
  • Zhou, Juan
  • Hung, Orlando
  • Shukla, Romesh
  • Whynot, Sara
  • Kuschnereit, Rieke
  • Küster, Inga
http://linked.open...ain/vavai/riv/wos
  • 000304504000012
issn
  • 0003-2999
number of pages
http://bibframe.org/vocab/doi
  • 10.1213/ANE.0b013e318251dada
http://localhost/t...ganizacniJednotka
  • 11150
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