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  • Introduction: The brain is one of the first organs affected clinically in sepsis. Microcirculatory alterations are suggested to be a critical component in the pathophysiology of sepsis. The aim of this study was to investigate the effects of recombinant human activated protein C (rhAPC) on the pial microcirculation in experimental endotoxemia using intravital microscopy. Our hypothesis is rhAPC protects pial microcirculation in endotoxemia.
  • Introduction: The brain is one of the first organs affected clinically in sepsis. Microcirculatory alterations are suggested to be a critical component in the pathophysiology of sepsis. The aim of this study was to investigate the effects of recombinant human activated protein C (rhAPC) on the pial microcirculation in experimental endotoxemia using intravital microscopy. Our hypothesis is rhAPC protects pial microcirculation in endotoxemia. (en)
Title
  • Activated protein C improves pial microcirculation in experimental endotoxemia in rats
  • Activated protein C improves pial microcirculation in experimental endotoxemia in rats (en)
skos:prefLabel
  • Activated protein C improves pial microcirculation in experimental endotoxemia in rats
  • Activated protein C improves pial microcirculation in experimental endotoxemia in rats (en)
skos:notation
  • RIV/00216208:11150/12:10126972!RIV13-MSM-11150___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 3
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http://linked.open...dnocenehoVysledku
  • 120938
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/12:10126972
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • releaseplasma extra; permeability; encephalopathy; lipopolysacharide; brain; severe sepsis; humna neutrophils; leukocyte adherence; plasma extravasation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [A4E4EC2254DE]
http://linked.open...i/riv/nazevZdroje
  • Microvascular Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 83
http://linked.open...iv/tvurceVysledku
  • Černý, Vladimír
  • Lehmann, Christian
  • Pavlovic, Dragan
  • Wendt, Michael
  • Zhou, Juan
  • Friedel, Claudius
  • Hung, Orlando
  • Schroeder, Henry
  • Shukla, Romesh
  • Whynot, Sara
  • Willecke, Julia
http://linked.open...ain/vavai/riv/wos
  • 000303690800003
issn
  • 0026-2862
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.mvr.2012.03.003
http://localhost/t...ganizacniJednotka
  • 11150
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