About: The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.jorganchem.2012.07.011
Description	A series of allyl molybdenum [(η3-C3H5)Mo(CO)2L2Cl], [(η3-C3H4COOMe)Mo(CO)2L2Br], cyclopentadienyl molybdenum [(η5-C5H4R)Mo(CO)2L2][BF4] (R = H, 4-MeOC6H4CH2, 3,4,5-(MeO)3C6H2CH2), indenyl molybdenum [(η5-C9H6R)Mo(CO)2L2][BF4] (R = H, 4-MeOC6H4CH2) and cyclopentadienyl tungsten compounds [(η5-C5H5)W(CO)2L2][BF4], where L2 is N,N'-chelating ligand, were synthesized and characterized. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution in the π-ligand has lower effect of on cytotoxicity than exchange of the N,N'-chelating ligand. Nevertheless, even this modification can lead to considerable enhance of cytotoxicity as was evidenced on the series of the indenyl molybdenum(II) compounds. A series of allyl molybdenum [(η3-C3H5)Mo(CO)2L2Cl], [(η3-C3H4COOMe)Mo(CO)2L2Br], cyclopentadienyl molybdenum [(η5-C5H4R)Mo(CO)2L2][BF4] (R = H, 4-MeOC6H4CH2, 3,4,5-(MeO)3C6H2CH2), indenyl molybdenum [(η5-C9H6R)Mo(CO)2L2][BF4] (R = H, 4-MeOC6H4CH2) and cyclopentadienyl tungsten compounds [(η5-C5H5)W(CO)2L2][BF4], where L2 is N,N'-chelating ligand, were synthesized and characterized. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution in the π-ligand has lower effect of on cytotoxicity than exchange of the N,N'-chelating ligand. Nevertheless, even this modification can lead to considerable enhance of cytotoxicity as was evidenced on the series of the indenyl molybdenum(II) compounds. (en)
Title	The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds (en)
skos:prefLabel	The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds (en)
skos:notation	RIV/00216208:11150/12:10124994!RIV13-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	October
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Řezáčová, Martina Foltánová, Karolína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	133289
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/12:10124994
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Leukemia therapy; Cytotoxicity; X-ray diffraction; Indenyl; Cyclopentadienyl; Molybdenum (en)
http://linked.open.../riv/klicoveSlovo	Molybdenum X-ray diffraction Cytotoxicity Cyclopentadienyl Indenyl Leukemia therapy
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[F744ACDA9677]
http://linked.open...i/riv/nazevZdroje	Journal of Organometallic Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	716
http://linked.open...iv/tvurceVysledku	Padělková, Zdeňka Vinklárek, Jaromír Řezáčová, Martina Honzíček, Jan Foltánová, Karolína Šebestová, Lucie
http://linked.open...ain/vavai/riv/wos	000307821700036
issn	0022-328X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jorganchem.2012.07.011
http://localhost/t...ganizacniJednotka	11150

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 107 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software