About: The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle

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About: The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs13105-012-0150-6
Description	The main purpose of this study was determining the effect of various doses of endotoxin on protein and amino acid metabolism in two types of rat skeletal muscle. Sepsis was induced by intraperitoneal administration of endotoxin in a dose of 1, 3 and 5 mg/kg body weithg (bw). After 24 h, extensor digitorum longus (EDL) and soleus (SOL) muscles were isolated and used for determination of total and myofibrillar proteolysis, protein synthesis, activity of cathepsins B and L, chymotrypsin-like activity of proteasome and amino acid release. The dose of 5 mg of endotoxin/kg bw induced the most significant changes in parameters of the protein and amino acid metabolism measured and could be therefore considered appropriate for studies of protein catabolism in young rat skeletal muscle at 24 h after endotoxin treatment. The main purpose of this study was determining the effect of various doses of endotoxin on protein and amino acid metabolism in two types of rat skeletal muscle. Sepsis was induced by intraperitoneal administration of endotoxin in a dose of 1, 3 and 5 mg/kg body weithg (bw). After 24 h, extensor digitorum longus (EDL) and soleus (SOL) muscles were isolated and used for determination of total and myofibrillar proteolysis, protein synthesis, activity of cathepsins B and L, chymotrypsin-like activity of proteasome and amino acid release. The dose of 5 mg of endotoxin/kg bw induced the most significant changes in parameters of the protein and amino acid metabolism measured and could be therefore considered appropriate for studies of protein catabolism in young rat skeletal muscle at 24 h after endotoxin treatment. (en)
Title	The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle (en)
skos:prefLabel	The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle (en)
skos:notation	RIV/00216208:11150/12:10124769!RIV13-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Holeček, Milan Kovařík, Miroslav Šišpera, Luděk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	132084
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/12:10124769
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	proteasome; protein metabolism; skeletal muscle; endotoxin (en)
http://linked.open.../riv/klicoveSlovo	endotoxin proteasome protein metabolism skeletal muscle
http://linked.open...odStatuVydavatele	ES - Španělské království
http://linked.open...ontrolniKodProRIV	[E23ABFBDA7EE]
http://linked.open...i/riv/nazevZdroje	Journal of Physiology and Biochemistry
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	68
http://linked.open...iv/tvurceVysledku	Holeček, Milan Kovařík, Miroslav Šišpera, Luděk Muthný, Tomáš
http://linked.open...ain/vavai/riv/wos	000307513500009
issn	1138-7548
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s13105-012-0150-6
http://localhost/t...ganizacniJednotka	11150

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