About: Short term pharmacological immobilization in macaque monkeys

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1111/j.1467-2995.2011.00637.x/pdf
Description	To develop a safe and effective immobilization protocol in rhesus monkeys, which is not based on dissociative anaesthetic agent. Animals Twenty rhesus monkeys, weighing 2.6-8.0 kg, 1-3 years of age, of both sexes. The monkeys received 50 mu g kg(-1) medetomidine, 0.25 mg kg(-1) midazolam and 5 mu g kg(-1) fentanyl with 150 IU hyaluronidase intramuscularly (IM). The animals were closely observed for behavioural changes and reaction to sound stimulus. Pulse rate and oxygen saturation of haemoglobin (SpO(2)) were monitored every 5 minutes, for 20 minutes. After this period, 250 mu g kg(-1) atipamezole or a placebo was administered IM and behavioural changes were closely observed. Full immobilization was observed after mean 269 +/- SD 116 seconds. Ten minutes after injection mean arterial oxygen saturation of haemoglobin was 94 +/- 4%, but did not fall significantly further. The median pulse rate was 116 beats minute(-1) 5 minutes after the administration of the drug. To develop a safe and effective immobilization protocol in rhesus monkeys, which is not based on dissociative anaesthetic agent. Animals Twenty rhesus monkeys, weighing 2.6-8.0 kg, 1-3 years of age, of both sexes. The monkeys received 50 mu g kg(-1) medetomidine, 0.25 mg kg(-1) midazolam and 5 mu g kg(-1) fentanyl with 150 IU hyaluronidase intramuscularly (IM). The animals were closely observed for behavioural changes and reaction to sound stimulus. Pulse rate and oxygen saturation of haemoglobin (SpO(2)) were monitored every 5 minutes, for 20 minutes. After this period, 250 mu g kg(-1) atipamezole or a placebo was administered IM and behavioural changes were closely observed. Full immobilization was observed after mean 269 +/- SD 116 seconds. Ten minutes after injection mean arterial oxygen saturation of haemoglobin was 94 +/- 4%, but did not fall significantly further. The median pulse rate was 116 beats minute(-1) 5 minutes after the administration of the drug. (en)
Title	Short term pharmacological immobilization in macaque monkeys Short term pharmacological immobilization in macaque monkeys (en)
skos:prefLabel	Short term pharmacological immobilization in macaque monkeys Short term pharmacological immobilization in macaque monkeys (en)
skos:notation	RIV/00216208:11150/11:10210299!RIV14-MSM-11150___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT11284)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Schreiberová, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	229149
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/11:10210299
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	primate; midazolam; medetomidine; fentanyl; anaesthesia; alpha(2)-adrenergic agonist (en)
http://linked.open.../riv/klicoveSlovo	fentanyl alpha(2)-adrenergic agonist medetomidine midazolam primate anaesthesia
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C3B24B352A3E]
http://linked.open...i/riv/nazevZdroje	Veterinary Anaesthesia and Analgesia
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Non-traditional application of anaesthetic drugs in disaster medicine
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Málek, Jiří Hess, Ladislav Schreiberová, Jitka Votava, Martin Štein, Karel
http://linked.open...ain/vavai/riv/wos	000293797700010
issn	1467-2987
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1467-2995.2011.00637.x
http://localhost/t...ganizacniJednotka	11150

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