About: Chromium Picolinate Induces DNA Damage, Senescence and Cell Death in Normal Colonic Fibroblasts

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About: Chromium Picolinate Induces DNA Damage, Senescence and Cell Death in Normal Colonic Fibroblasts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chromim picolinate (CrPic) is used as a nutritional supplement to enhance insulin sensitivity, improve glucose blood levels and reduce weight. Despite its supposed safety, there have been conflicting reports over its potential cytotoxicity and genotoxicity in selected cell types. Chromium picolinate is mostly administered orally and after its absorption in digestive system it acts in blood stream. Cells in digestive tract are therefore repeatedly exposed to this chemical and until now no study has addressed biological outcomes of such interactions. The purpose of this work was to investigate the effects and mechanisms of exposure of normal colonic fibroblasts to CrPic over period of several weeks. Our results indicate that CrPic has weak genotoxic as well as epigenetic effects on colonic fibroblasts. Furthermore, in thus exposed fibroblasts p38- dependent stress signalig is activated with resulting cell cycle disturbances, induced senescence and cellular degeneration bearing features of apoptosis and autophagic cell death. Specific pharmacological inhibition of these processes confirmed multivariate cellular stress response to CrPic and suggested that this chemical may potentially endanger cell populations in digestive system over longer-term use. Chromim picolinate (CrPic) is used as a nutritional supplement to enhance insulin sensitivity, improve glucose blood levels and reduce weight. Despite its supposed safety, there have been conflicting reports over its potential cytotoxicity and genotoxicity in selected cell types. Chromium picolinate is mostly administered orally and after its absorption in digestive system it acts in blood stream. Cells in digestive tract are therefore repeatedly exposed to this chemical and until now no study has addressed biological outcomes of such interactions. The purpose of this work was to investigate the effects and mechanisms of exposure of normal colonic fibroblasts to CrPic over period of several weeks. Our results indicate that CrPic has weak genotoxic as well as epigenetic effects on colonic fibroblasts. Furthermore, in thus exposed fibroblasts p38- dependent stress signalig is activated with resulting cell cycle disturbances, induced senescence and cellular degeneration bearing features of apoptosis and autophagic cell death. Specific pharmacological inhibition of these processes confirmed multivariate cellular stress response to CrPic and suggested that this chemical may potentially endanger cell populations in digestive system over longer-term use. (en)
Title	Chromium Picolinate Induces DNA Damage, Senescence and Cell Death in Normal Colonic Fibroblasts Chromium Picolinate Induces DNA Damage, Senescence and Cell Death in Normal Colonic Fibroblasts (en)
skos:prefLabel	Chromium Picolinate Induces DNA Damage, Senescence and Cell Death in Normal Colonic Fibroblasts Chromium Picolinate Induces DNA Damage, Senescence and Cell Death in Normal Colonic Fibroblasts (en)
skos:notation	RIV/00216208:11150/11:10124908!RIV13-MSM-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620820)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Rudolf, Emil
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	190333
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/11:10124908
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell death; senescence; DNA damage; colonic fibroblasts; Chromium picolinate (en)
http://linked.open.../riv/klicoveSlovo	Chromium picolinate DNA damage cell death colonic fibroblasts senescence
http://linked.open...ontrolniKodProRIV	[670C5692C7F0]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...vEdiceCisloSvazku	Neuveden
http://linked.open...i/riv/nazevZdroje	Chromium: Environmental, Medical and Materials Studies
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	384 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Rudolf, Emil
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
number of pages	15 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Nova Science Publishers
https://schema.org/isbn	978-1-61122-656-0
http://localhost/t...ganizacniJednotka	11150

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