About: A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)

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About: A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.springerlink.com/content/p1083l5308018434/fulltext.pdf
Description	The study compared the pharmacokinetics, tissue distribution, and urinary excretion of platinum in rats after single oral doses of LA-12 and satraplatin. Characteristics of platinum exposure evaluated in the plasma, plasma ultrafiltrate and kidney and liver tissues. In the dose range of 37.5-300mg/kg, platinum concentrations increased less than in the proportion to the dose and, the fraction of dose exctreted in urine decreased. For both drugs, a dose-related decrease in the extent of oral bioavailability was observed most likely due to saturable intestinal absorption. The study compared the pharmacokinetics, tissue distribution, and urinary excretion of platinum in rats after single oral doses of LA-12 and satraplatin. Characteristics of platinum exposure evaluated in the plasma, plasma ultrafiltrate and kidney and liver tissues. In the dose range of 37.5-300mg/kg, platinum concentrations increased less than in the proportion to the dose and, the fraction of dose exctreted in urine decreased. For both drugs, a dose-related decrease in the extent of oral bioavailability was observed most likely due to saturable intestinal absorption. (en)
Title	A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) (en)
skos:prefLabel	A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) (en)
skos:notation	RIV/00216208:11150/11:10106142!RIV12-MSM-11150___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Chládek, Jaroslav Chládková, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	183681
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/11:10106142
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Wistar rat; Pharmacokinetics; Platinum anti-cancer drugs (en)
http://linked.open.../riv/klicoveSlovo	Pharmacokinetics Platinum anti-cancer drugs Wistar rat
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[3E77523D0880]
http://linked.open...i/riv/nazevZdroje	Cancer Chemotherapy and Pharmacology
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Chlubnová, Hana Chládek, Jaroslav Chládková, Jiřina Hrušková, Veronika Kroutil, Aleš Mistr, Adolf Semerád, Martin Sova, Petr
http://linked.open...ain/vavai/riv/wos	000291036500004
issn	0344-5704
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00280-010-1411-0
http://localhost/t...ganizacniJednotka	11150

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