About: The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats

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About: The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomed.cas.cz/physiolres/pdf/60/60_317.pdf
Description	The aim of this work was to establish and characterize a nutritional model (using a high-fat diet for 3 or 6 weeks) of non-alcoholic fatty liver disease (NAFLD) in male Wistar and Sprague-Dawley rats. Feeding with high fat diet induced small-droplet or mixed hepatic steatosis without focal inflammation and necrosis. We observed changes in liver glutathione levels, malondialdehyde production and expression of UCP-2 mRNA, but not differences in serum biochemical parameters. The present study showed that male Wistar and Sprague-Dawley rats fed by high-fat diet developed comparable simple steatosis without signs of progression to non-alcoholic steatohepatitis. The aim of this work was to establish and characterize a nutritional model (using a high-fat diet for 3 or 6 weeks) of non-alcoholic fatty liver disease (NAFLD) in male Wistar and Sprague-Dawley rats. Feeding with high fat diet induced small-droplet or mixed hepatic steatosis without focal inflammation and necrosis. We observed changes in liver glutathione levels, malondialdehyde production and expression of UCP-2 mRNA, but not differences in serum biochemical parameters. The present study showed that male Wistar and Sprague-Dawley rats fed by high-fat diet developed comparable simple steatosis without signs of progression to non-alcoholic steatohepatitis. (en)
Title	The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats (en)
skos:prefLabel	The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats (en)
skos:notation	RIV/00216208:11150/11:10105379!RIV12-GA0-11150___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GP305/08/P184), S, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Roušar, Tomáš Hroch, Miloš Staňková, Pavla Bolehovská, Radka Garnol, Tomáš Mazurová, Yvona Kremláček, Jan Červinková, Zuzana Kučera, Otto
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	196421
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/11:10105379
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytokines; Oxidative stress; Fatty Liver (en)
http://linked.open.../riv/klicoveSlovo	Oxidative stress Fatty Liver Cytokines
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[568BD5D7E3C0]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Is the liver affected by non-alcoholic liver disease (NAFLD) more sensitive to toxic injury?
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Roušar, Tomáš Kučera, Otto Lotková, Halka Staňková, Pavla Červinková, Zuzana Bolehovská, Radka Garnol, Tomáš Hroch, Miloš Mazurová, Yvona
http://linked.open...ain/vavai/riv/wos	000291154900015
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0862-8408
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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