About: Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome

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About: Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome - a description of two cases Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Only a few cases of pneumocystis pneumonia (PCP) in Cushing's syndrome have been published in the literature so far. In the majority of these patients, the pneumonia occurred after reduction of the hypercortisolism with medicamentous treatment. We report two cases of PCP during conservative treatment of hypercortisolism. We describe clinical, imaging and laboratory findings in two patients and review published cases of pneumocystits pneumonia in Cushing''s syndrome. A 60-year-old woman and 20-year-old man with Cushing''s syndrome due to ectopic ACTH syndrome were treated at our department. Both developed pneumocystis pneumonia early after treatment with ketoconazole and ethomidate bromide had been introduced and the levels of cortisol rapidly decreased. PCP prophylaxis in patients with high cortisolemia should be started before treatment of hypercortisolism in current practice. Gradual lowering of plasma cortisol should also reduce the risk of infection by Pneumocystis jiroveci. Only a few cases of pneumocystis pneumonia (PCP) in Cushing's syndrome have been published in the literature so far. In the majority of these patients, the pneumonia occurred after reduction of the hypercortisolism with medicamentous treatment. We report two cases of PCP during conservative treatment of hypercortisolism. We describe clinical, imaging and laboratory findings in two patients and review published cases of pneumocystits pneumonia in Cushing''s syndrome. A 60-year-old woman and 20-year-old man with Cushing''s syndrome due to ectopic ACTH syndrome were treated at our department. Both developed pneumocystis pneumonia early after treatment with ketoconazole and ethomidate bromide had been introduced and the levels of cortisol rapidly decreased. PCP prophylaxis in patients with high cortisolemia should be started before treatment of hypercortisolism in current practice. Gradual lowering of plasma cortisol should also reduce the risk of infection by Pneumocystis jiroveci. (en)
Title	Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome - a description of two cases Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome - a description of two cases (en)
skos:prefLabel	Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome - a description of two cases Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome - a description of two cases (en)
skos:notation	RIV/00216208:11150/11:10105266!RIV12-MZ0-11150___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT11344)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zavřelová, Alžběta Cerman, Jaroslav Čáp, Jan Radocha, Jakub Gabalec, Filip Havel, Eduard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	220645
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/11:10105266
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glucocorticoids; opportunistic infection; pneumocystis; Cushing's disease; Cushing's syndrome (en)
http://linked.open.../riv/klicoveSlovo	glucocorticoids Cushing's syndrome Cushing's disease opportunistic infection pneumocystis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[FE5833F51249]
http://linked.open...i/riv/nazevZdroje	Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Kralove
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Quantitative analysis of somatostatin receptors in pituitary adenomas.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Cerman, Jaroslav Havel, Eduard Radocha, Jakub Zavřelová, Alžběta Čáp, Jan Gabalec, Filip Svilias, Ioannis
issn	1211-4286
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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