About: Radiosensitivity of CD3-CD8+CD56+ NK cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effect of lower doses (0.5-3.0 Gy) of gamma radiation on radiosensitivity of CD3-/CD8+ NK cells subpopulation isolated from the peripheral blood of healthy volunteers was studied 48 h after the irradiation. Only a subtle increase in terms of induction of apoptosis (A+cells), was observed in Annexin positive CD3-/CD8+ NK cells. The assessment of the relative presence of CD3-/CD8+ NK cells in Annexin negative populations of lymphocytes considerably contributes to the elimination of individual variability and could be useful in biodosimetry. Living CD3-/CD8+; Annexin negative NK cells were analyzed using five-color flow cytometry 16 hours after irradiation by the doses of 1-10 Gy. The study was carried out on NK cells subsets CD3-/CD8 - CD16+, CD56(dim) and CD56(bright). NK cells characterized with their low-density expression of CD56(dim) are more cytotoxic and express CD16. The effect of lower doses (0.5-3.0 Gy) of gamma radiation on radiosensitivity of CD3-/CD8+ NK cells subpopulation isolated from the peripheral blood of healthy volunteers was studied 48 h after the irradiation. Only a subtle increase in terms of induction of apoptosis (A+cells), was observed in Annexin positive CD3-/CD8+ NK cells. The assessment of the relative presence of CD3-/CD8+ NK cells in Annexin negative populations of lymphocytes considerably contributes to the elimination of individual variability and could be useful in biodosimetry. Living CD3-/CD8+; Annexin negative NK cells were analyzed using five-color flow cytometry 16 hours after irradiation by the doses of 1-10 Gy. The study was carried out on NK cells subsets CD3-/CD8 - CD16+, CD56(dim) and CD56(bright). NK cells characterized with their low-density expression of CD56(dim) are more cytotoxic and express CD16. (en)
Title	Radiosensitivity of CD3-CD8+CD56+ NK cells Radiosensitivity of CD3-CD8+CD56+ NK cells (en)
skos:prefLabel	Radiosensitivity of CD3-CD8+CD56+ NK cells Radiosensitivity of CD3-CD8+CD56+ NK cells (en)
skos:notation	RIV/00216208:11150/10:10081136!RIV11-MO0-11150___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(OVUOFVZ200806), V, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Stoklasová, Alena Řezáčová, Martina Vokurková, Doris
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	283781
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/10:10081136
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aptosis; CD16; CD56bright NK cells; Ionizing radiation; Biodosimetry; NK cells (en)
http://linked.open.../riv/klicoveSlovo	NK cells Ionizing radiation Biodosimetry CD56bright NK cells aptosis CD16
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[6ADEA3A77987]
http://linked.open...i/riv/nazevZdroje	Radiation Measurements
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Bláha, Václav Stoklasová, Alena Vávrová, Jiřina Vokurková, Doris Řezáčová, Martina Šinkora, Jiří
http://linked.open...ain/vavai/riv/wos	000283466200006
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	1350-4487
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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