About: Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy

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About: Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	S-adenosylmethionine (SAMe) is a key metabolite regulating growth, differentiation and death of hepatocytes. Experimentally, exogenous SAMe has been documented to attenuate hepatocarcinogenesis. The aim of our study was to evaluate the effect of SAMe on proliferation of hepatocytes that are not cancerously transformed. The results have documented the inhibition of the liver regeneration by SAMe that may be mediated by the suppression of liver fat accumulation. Cell GSH level correlating with the growth rate was not affected by SAMe. Prevention from the decrease in the intracellular content of SAMe, as a factor attenuating regeneration remains to be verified. S-adenosylmethionine (SAMe) is a key metabolite regulating growth, differentiation and death of hepatocytes. Experimentally, exogenous SAMe has been documented to attenuate hepatocarcinogenesis. The aim of our study was to evaluate the effect of SAMe on proliferation of hepatocytes that are not cancerously transformed. The results have documented the inhibition of the liver regeneration by SAMe that may be mediated by the suppression of liver fat accumulation. Cell GSH level correlating with the growth rate was not affected by SAMe. Prevention from the decrease in the intracellular content of SAMe, as a factor attenuating regeneration remains to be verified. (en)
Title	Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy (en)
skos:prefLabel	Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy (en)
skos:notation	RIV/00216208:11150/10:10078877!RIV11-MZ0-11150___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NS9739), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Roušar, Tomáš Garnol, Tomáš Kremláček, Jan Červinková, Zuzana Kučera, Otto Kohoutek, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	256139
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/10:10078877
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	S-adenosylmethionine; liver regeneration; partial hepatectomy (en)
http://linked.open.../riv/klicoveSlovo	partial hepatectomy S-adenosylmethionine liver regeneration
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[109BD369FAE2]
http://linked.open...i/riv/nazevZdroje	General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Can Statins Attenuate a development of cholestatic liver disease?
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Roušar, Tomáš Kohoutek, Lukáš Kučera, Otto Lotková, Halka Červinková, Zuzana Garnol, Tomáš Šiller, Jiří
http://linked.open...ain/vavai/riv/wos	000277136800010
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0231-5882
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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