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  • The recently recognized cytokine interleukin-33 and its receptor ST2 play a favorable role during atherogenesis by inducing a Th1?Th2 shift of the immune response. IL-33 also protects the failing human heart from harmful biomechanical forces which lead to cardiomyocyte hypertrophy and exaggerated interstitial fibrosis. IL-33 inevitably displays side effects common to other Th2 cytokines, the most grave of which is a predisposition to allergic reactions. IL-33 is a nuclear transcription factor of endothelial cells. As such, it is abundant in nonproliferating vessels. Its down-regulation is required for angiogenesis, which may be profitable in wound healing or deleterious in tumor growth.
  • The recently recognized cytokine interleukin-33 and its receptor ST2 play a favorable role during atherogenesis by inducing a Th1?Th2 shift of the immune response. IL-33 also protects the failing human heart from harmful biomechanical forces which lead to cardiomyocyte hypertrophy and exaggerated interstitial fibrosis. IL-33 inevitably displays side effects common to other Th2 cytokines, the most grave of which is a predisposition to allergic reactions. IL-33 is a nuclear transcription factor of endothelial cells. As such, it is abundant in nonproliferating vessels. Its down-regulation is required for angiogenesis, which may be profitable in wound healing or deleterious in tumor growth. (en)
Title
  • The counter-regulation of atherogenesis: a role for interleukin-33
  • The counter-regulation of atherogenesis: a role for interleukin-33 (en)
skos:prefLabel
  • The counter-regulation of atherogenesis: a role for interleukin-33
  • The counter-regulation of atherogenesis: a role for interleukin-33 (en)
skos:notation
  • RIV/00216208:11150/10:10061796!RIV11-MSM-11150___
http://linked.open...avai/riv/aktivita
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  • Z(MSM0021620812)
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  • 3
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  • 252255
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  • RIV/00216208:11150/10:10061796
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  • Angiogenesis; Antibodies; Atherosclerosis; Th2 immune response; ST2 receptor; Interleukin-33 (en)
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  • CZ - Česká republika
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  • [F1C58AF6973B]
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  • Acta medica (Hradec Kralove) / Universitas Carolina, Facultas Medica Hradec Kralove
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  • 53
http://linked.open...iv/tvurceVysledku
  • Krejsek, Jan
  • Koláčková, Martina
  • Kuneš, Pavel
  • Holubcová, Zdeňka
http://linked.open...n/vavai/riv/zamer
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  • 1211-4286
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  • 11150
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