About: Plasma filtration in the treatment of Graves' ophthalmopathy: A randomized study

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to perform a randomized study to evaluate the role of plasma filtration in the treatment of severe thyroid-associated ophthalmopathy (TAO). All immunoglobulin classes as well as autoantibodies directed against thyroglobulin, thyroid peroxidase, and TSH receptor exhibited statistically significantly decreases. Although the clinical activity score (CAS) dropped in all patients, it occurred more rapidly in patients treated with plasma filtration. The CAS difference between the two groups was statistically significant (p = 0.027). The amplitude of visual evoked potentials improved after 3 months in the plasma filtration group. At the end of the study, there was no difference between patients treated with aphereses and the control group. We conclude that apheresis can decrease disease activity more rapidly than standard high-dose IV glucocorticoid therapy. Whether this superior treatment effect could potentially avoid surgical procedures remains to be determined.10.1002/jca.20244 The aim of this study was to perform a randomized study to evaluate the role of plasma filtration in the treatment of severe thyroid-associated ophthalmopathy (TAO). All immunoglobulin classes as well as autoantibodies directed against thyroglobulin, thyroid peroxidase, and TSH receptor exhibited statistically significantly decreases. Although the clinical activity score (CAS) dropped in all patients, it occurred more rapidly in patients treated with plasma filtration. The CAS difference between the two groups was statistically significant (p = 0.027). The amplitude of visual evoked potentials improved after 3 months in the plasma filtration group. At the end of the study, there was no difference between patients treated with aphereses and the control group. We conclude that apheresis can decrease disease activity more rapidly than standard high-dose IV glucocorticoid therapy. Whether this superior treatment effect could potentially avoid surgical procedures remains to be determined.10.1002/jca.20244 (en)
Title	Plasma filtration in the treatment of Graves' ophthalmopathy: A randomized study Plasma filtration in the treatment of Graves' ophthalmopathy: A randomized study (en)
skos:prefLabel	Plasma filtration in the treatment of Graves' ophthalmopathy: A randomized study Plasma filtration in the treatment of Graves' ophthalmopathy: A randomized study (en)
skos:notation	RIV/00216208:11150/10:10057361!RIV11-MZ0-11150___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NR9181)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ceeová, Věra Bláha, Milan Čáp, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	279113
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/10:10057361
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Graves' ophthalmopathy; clinical activity score; plasma filtration; treatment; thyroid-associated ophthalmopathy (en)
http://linked.open.../riv/klicoveSlovo	plasma filtration treatment Graves' ophthalmopathy clinical activity score thyroid-associated ophthalmopathy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[66ABB05A094C]
http://linked.open...i/riv/nazevZdroje	Journal of Clinical Apheresis
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Hemorheopheresis in treatment of severe thyroid associated orbitopathy, the role of changes in selected pathogenetic indicators
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Bláha, Milan Vlček, Petr Čáp, Jan Rezek, P. Ceeová, Věra Škácha, Michal
http://linked.open...ain/vavai/riv/wos	000281171800005
issn	0733-2459
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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