About: Comparison of Genetic Distance Measures Using Human SNP Genotype Data

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Quantification of the genetic distance between populations is instrumental in many genetic research initiatives, and a large number of formulas for this purpose have been proposed. However, selection of an appropriate measure for assessing genetic distance between real-world human populations that diverged as a result of mechanisms that are not fully known can be a challenging task. We compared results from nine widely used genetic distance measures to high-density whole-genome SNP genotype data obtained on individuals from 51 world populations. Using population trees and generalized analysis of molecular variance, we founcl that contradictory inferences could be drawn from analyses that used different distance measures. We determined the grouping of the distance measures in terms of similarity and consistency of their values using concordance, consistency, and Procrustes analyses. Quantification of the genetic distance between populations is instrumental in many genetic research initiatives, and a large number of formulas for this purpose have been proposed. However, selection of an appropriate measure for assessing genetic distance between real-world human populations that diverged as a result of mechanisms that are not fully known can be a challenging task. We compared results from nine widely used genetic distance measures to high-density whole-genome SNP genotype data obtained on individuals from 51 world populations. Using population trees and generalized analysis of molecular variance, we founcl that contradictory inferences could be drawn from analyses that used different distance measures. We determined the grouping of the distance measures in terms of similarity and consistency of their values using concordance, consistency, and Procrustes analyses. (en)
Title	Comparison of Genetic Distance Measures Using Human SNP Genotype Data Comparison of Genetic Distance Measures Using Human SNP Genotype Data (en)
skos:prefLabel	Comparison of Genetic Distance Measures Using Human SNP Genotype Data Comparison of Genetic Distance Measures Using Human SNP Genotype Data (en)
skos:notation	RIV/00216208:11150/09:10081870!RIV11-MSM-11150___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Libiger, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	307717
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:10081870
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	humna genome diversity panel (HGDP); Cavalli-Sforze and Edwards distance; genetic distance; population genetics (en)
http://linked.open.../riv/klicoveSlovo	population genetics genetic distance Cavalli-Sforze and Edwards distance humna genome diversity panel (HGDP)
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[31CDC14C05BB]
http://linked.open...i/riv/nazevZdroje	Human Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	81
http://linked.open...iv/tvurceVysledku	Schork, Nicholas J. Libiger, Ondřej Nievergelt, Caroline M.
http://linked.open...ain/vavai/riv/wos	000281643600001
issn	0018-7143
number of pages	17 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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