About: DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The purpose of this study was to investigate the initial stages of Cr (VI)-induced DNA damaging in normal human skin fibroblasts. Primary human skin fibroblasts were exposed to Cr (VI) at a concentration range of 1-50 µM during 24 h. Our results confirm that Cr (VI) dose-dependently stimulates both directly (via its reactive metabolic intermediates) and indirectly (through generated oxidative stress) DNA damaging which results in the activation of DNA damage response pathway during 24 h of treatment. The important members of this pathway include ATM/ATR kinases which stimulate their downstream targets Chk1, Chk2 and p53 in mediating transient G2/M cell cycle arrest and activating cell death characterized by the specific cleavage of PARP. Inhibition of ATM/ATR pathway and suppresion of oxidative stress in exposed cells significantly suppressed cell damage characterized by specific PARP cleavage. The purpose of this study was to investigate the initial stages of Cr (VI)-induced DNA damaging in normal human skin fibroblasts. Primary human skin fibroblasts were exposed to Cr (VI) at a concentration range of 1-50 µM during 24 h. Our results confirm that Cr (VI) dose-dependently stimulates both directly (via its reactive metabolic intermediates) and indirectly (through generated oxidative stress) DNA damaging which results in the activation of DNA damage response pathway during 24 h of treatment. The important members of this pathway include ATM/ATR kinases which stimulate their downstream targets Chk1, Chk2 and p53 in mediating transient G2/M cell cycle arrest and activating cell death characterized by the specific cleavage of PARP. Inhibition of ATM/ATR pathway and suppresion of oxidative stress in exposed cells significantly suppressed cell damage characterized by specific PARP cleavage. (en)
Title	DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium (en)
skos:prefLabel	DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium (en)
skos:notation	RIV/00216208:11150/09:00208684!RIV10-MSM-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620820)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Rudolf, Kamil Červinka, Miroslav Rudolf, Emil Králová, Věra Schröterová, Ladislava
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	311000
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208684
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hexavalent chromium; dermal fibroblasts DNA damage signaling; p53 (en)
http://linked.open.../riv/klicoveSlovo	hexavalent chromium p53 dermal fibroblasts DNA damage signaling
http://linked.open...ontrolniKodProRIV	[DA4D39161DEE]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...vEdiceCisloSvazku	1.
http://linked.open...i/riv/nazevZdroje	New Research on DNA Damage
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...v/pocetStranKnihy	410 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Rudolf, Emil Rudolf, Kamil Červinka, Miroslav Králová, Věra Schröterová, Ladislava
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
number of pages	18 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Nova Sciense Publishers
https://schema.org/isbn	978-1-60456-581-2
http://localhost/t...ganizacniJednotka	11150

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