About: Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620

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About: Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated its mechanisms in metastatic SW620 cell line. Our results indicate that in SW620 cells SF acts to induce multivariate cascades including DNA-damage response pathway whose proapoptotic signaling is nevertheless reduced owing to the mutant status of p53 and caspase-2-JNK pathway which seems to complement and enhance p53-dependent signaling, however only in wild-type p53. Furthermore, both pathways require the active role of mitochondria and do not depend on generation of ROS, making SF an attractive chemopreventive agent whose antitumor properties should be further investigated in colon cancer. We investigated its mechanisms in metastatic SW620 cell line. Our results indicate that in SW620 cells SF acts to induce multivariate cascades including DNA-damage response pathway whose proapoptotic signaling is nevertheless reduced owing to the mutant status of p53 and caspase-2-JNK pathway which seems to complement and enhance p53-dependent signaling, however only in wild-type p53. Furthermore, both pathways require the active role of mitochondria and do not depend on generation of ROS, making SF an attractive chemopreventive agent whose antitumor properties should be further investigated in colon cancer. (en)
Title	Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620 Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620 (en)
skos:prefLabel	Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620 Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620 (en)
skos:notation	RIV/00216208:11150/09:00208664!RIV10-MSM-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Andělová, Hana Červinka, Miroslav Rudolf, Emil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	301837
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208664
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sulforaphane; apoptosis; DNA-damage response; caspases; colon cancer; p53 (en)
http://linked.open.../riv/klicoveSlovo	caspases p53 sulforaphane DNA-damage response apoptosis colon cancer
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[44BFA39D306A]
http://linked.open...i/riv/nazevZdroje	Food and Chemical Toxicology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Rudolf, Emil Červinka, Miroslav Andělová, Hana
http://linked.open...ain/vavai/riv/wos	000269432000030
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0278-6915
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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