About: Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis

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About: Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The study compared the bioavailability of methotrexate administered oraly and intravenously to children with idiopathic artrithis. The results show that unlike for subcutaneous route, the pharmacokinetics of oral methotrexte are nonlinear within the range of 6.1-28.6 mg/m2 most probably due to saturable intestinal absorption. The study compared the bioavailability of methotrexate administered oraly and intravenously to children with idiopathic artrithis. The results show that unlike for subcutaneous route, the pharmacokinetics of oral methotrexte are nonlinear within the range of 6.1-28.6 mg/m2 most probably due to saturable intestinal absorption. (en)
Title	Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis (en)
skos:prefLabel	Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis (en)
skos:notation	RIV/00216208:11150/09:00208627!RIV10-MZ0-11150___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1P05OC066), P(NE6681)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Chládek, Jaroslav Chládková, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	325731
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208627
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	methotrexate; bioavailability; idiopathic arthritis; children (en)
http://linked.open.../riv/klicoveSlovo	children idiopathic arthritis bioavailability methotrexate
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[33BBBFC1522E]
http://linked.open...i/riv/nazevZdroje	Clinical and Experimental Rheumatology
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Physiologically based modelling of nitric oxide disposition and effects in airways disease Relationship of intracellular methotrexate concentration to clinical and laboratory parameters of disease activity in children with idiopathic arthritis
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Chládek, Jaroslav Chládková, Jiřina Doležalová, Pavla Tuková, Jana Němcová, Dana
http://linked.open...ain/vavai/riv/wos	000274264700028
issn	0392-856X
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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