| Attributes | Values |
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| rdf:type
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| Description
| - Tissue factor is a cell surface protein that is expressed constitutively by monocytes, macrophages and fibroblasts, but also by some other cells in response to a variety of stimuli. The main function of the tissue factor is to form a complex with factors VII/VIIa that converts factors IX and X to their active forms. Tissue factors is also involved in the pathophysiology of systemic inflammatory disorders, coagulopathies, atherosclerotic disease, tumor angiogenesis and metastasis. Increased tissue factor expression either locally in the coronary plaques or systematically on circulating blood elements of patients with acute coronary syndromes may be responsible for increased thrombin generation, thus leading to platelet activation and fibrin formation. Tissue factor therefore plays a pivotal role in the initation of thrombotic complications in patients with coronary artery disease.
- Tissue factor is a cell surface protein that is expressed constitutively by monocytes, macrophages and fibroblasts, but also by some other cells in response to a variety of stimuli. The main function of the tissue factor is to form a complex with factors VII/VIIa that converts factors IX and X to their active forms. Tissue factors is also involved in the pathophysiology of systemic inflammatory disorders, coagulopathies, atherosclerotic disease, tumor angiogenesis and metastasis. Increased tissue factor expression either locally in the coronary plaques or systematically on circulating blood elements of patients with acute coronary syndromes may be responsible for increased thrombin generation, thus leading to platelet activation and fibrin formation. Tissue factor therefore plays a pivotal role in the initation of thrombotic complications in patients with coronary artery disease. (en)
- Tkáňový faktor je protein buněčné stěny a je exprimován nejen v monocytech, makrofázích a fibroblastech, ale i v jiných buňkách v odpověď na řadu stimulů. Tkáňový faktor tvoří komplex s aktivovaným faktorem VII a konvertuje faktory IX a X do jejich aktivních forem. Tkáňový faktor se účastní v patofyziologických procesech spojených se zánětlivými procesy, koagulopatiemi, aterosklerózou, nádorovou angiogenézou a metastázami. Vzestup exprese tkáňového faktoru lokálně nebo v cirkulujících elementech u nemocných s akutním koronárním syndromem může být zodpovědný za zvýšenou tvorbu trombinu s následnou aktivací destiček a tvorbou fibrinu. (cs)
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| Title
| - Plasma tissue factor in coronary artery disease. Further step to the understanding of the basic mechanisms of coronary artery thrombosis
- Plasmatický tkáňový faktor u koronární nemoci. Další krok v pochopení základního mechanismu trombózy věnčité tepny. (cs)
- Plasma tissue factor in coronary artery disease. Further step to the understanding of the basic mechanisms of coronary artery thrombosis (en)
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| skos:prefLabel
| - Plasma tissue factor in coronary artery disease. Further step to the understanding of the basic mechanisms of coronary artery thrombosis
- Plasmatický tkáňový faktor u koronární nemoci. Další krok v pochopení základního mechanismu trombózy věnčité tepny. (cs)
- Plasma tissue factor in coronary artery disease. Further step to the understanding of the basic mechanisms of coronary artery thrombosis (en)
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| skos:notation
| - RIV/00216208:11150/08:00107006!RIV09-MSM-11150___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/08:00107006
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - coronary artery disease; coronary thrombosis; tissue factor (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Blažek, Martin
- Dušek, Jaroslav
- Vojáček, Jan
- Bis, Josef
- Šťásek, Josef
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| http://linked.open...ain/vavai/riv/wos
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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