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| rdf:type
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| Description
| - The Goeckerman regimen (GR) involves the dermal application of a crude coal tar (polycyclic aromatic hydrocarbon, PAH) and exposure to ultraviolet (UV) radiation. Both PAH and UV radiation exhibit immunosuppressive activity. This study describes the changes in the serum levels of the pro-inflammatory cytokine interleukin-12 (IL-12) and the anti-inflammatory cytokine IL-10 in patients with psoriasis (n = 55) treated with GR. The results indicate a strong pro-inflammatory effect of IL-12 in the immunopathogenesis of psoriasis, and confirm the immunosuppressive and anti-inflammatory effect of GR. IL-10 seems to be a promising individual marker for a positive effect of GR therapy.
- The Goeckerman regimen (GR) involves the dermal application of a crude coal tar (polycyclic aromatic hydrocarbon, PAH) and exposure to ultraviolet (UV) radiation. Both PAH and UV radiation exhibit immunosuppressive activity. This study describes the changes in the serum levels of the pro-inflammatory cytokine interleukin-12 (IL-12) and the anti-inflammatory cytokine IL-10 in patients with psoriasis (n = 55) treated with GR. The results indicate a strong pro-inflammatory effect of IL-12 in the immunopathogenesis of psoriasis, and confirm the immunosuppressive and anti-inflammatory effect of GR. IL-10 seems to be a promising individual marker for a positive effect of GR therapy. (en)
- Goeckermanova metoda (GR) zahrnuje dermální aplikaci kamenouhelného dehtu (polycyklické aromatické uhlovodíky, PAH) a expozici (UV) a ultrafialovému záření. Jak PAH tak UV záření vyvolávají imunosupresivní aktivitu. Studie popisovala změny starých hladin pro-zánětového cytokinu interleukinu-12 (IL-12) a proti-zánětového cytokinu IL-10 u pacientů s prosiázou (n=55) léčených GR. Výsledky indikovaly silný protizánětový efekt IL-12 v imunopatogenezi psoriázy a potvrdily imunosupresivní a proti zánětový efekt GR. IL-10 se jevil jako slibný individuální ukazatel pro hodnocení pozitivního efektu GR léčby. (cs)
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| Title
| - Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen
- Sérové hladiny pro-zánětového cytokinu interleukinu-12 a proti-zánětového cytokinu interleukinu-10 u pacientů s psoriázou léčených Goeckermanovou metodou (cs)
- Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen (en)
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| skos:prefLabel
| - Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen
- Sérové hladiny pro-zánětového cytokinu interleukinu-12 a proti-zánětového cytokinu interleukinu-10 u pacientů s psoriázou léčených Goeckermanovou metodou (cs)
- Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen (en)
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| skos:notation
| - RIV/00216208:11150/08:00106743!RIV09-MZ0-11150___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/08:00106743
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - interleukin-12; interleukin-10; psoriasis; Goeckerman regimen; polycyclic aromatic hydrocarbon (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - International Journal of Dermatology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Andrýs, Ctirad
- Ettler, Karel
- Krejsek, Jan
- Kremláček, Jan
- Fiala, Zdeněk
- Borská, Lenka
- Hamáková, Květoslava
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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