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| rdf:type
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| Description
| - Carcinosarcomas (CSs) are rare biphasic neoplasms of the female genital tract. The occurrence of non-epithelial or non-mesenchymal differentiations in CSc is extremely rare. A case of a 54-year-old woman with a uterine tumor showing histological, immunohistochemical, and ultrastructural features of CS with melanocytic differentiation. It was a 7.0x5.6 cm polypoid tumor arising from endometrium and metastasizing in the abdominal cavity as a malignant melanoma - the most aggressive component of CS. Despite adjuvant chemotherapy, she died 8 months after diagnosis due to the metastatic spread of CS. In line with current knowledge, we assess the melanocytic differentiation as one of differentiation line with the ability of multidirectional stem cell differentiation. We discuss possible pathogenesis of this lesion and the role of tamoxifen in its development. To the best of our knowledge, only one case of uterine CS with melanocytic differentiation has been reported in the English literature.
- Carcinosarcomas (CSs) are rare biphasic neoplasms of the female genital tract. The occurrence of non-epithelial or non-mesenchymal differentiations in CSc is extremely rare. A case of a 54-year-old woman with a uterine tumor showing histological, immunohistochemical, and ultrastructural features of CS with melanocytic differentiation. It was a 7.0x5.6 cm polypoid tumor arising from endometrium and metastasizing in the abdominal cavity as a malignant melanoma - the most aggressive component of CS. Despite adjuvant chemotherapy, she died 8 months after diagnosis due to the metastatic spread of CS. In line with current knowledge, we assess the melanocytic differentiation as one of differentiation line with the ability of multidirectional stem cell differentiation. We discuss possible pathogenesis of this lesion and the role of tamoxifen in its development. To the best of our knowledge, only one case of uterine CS with melanocytic differentiation has been reported in the English literature. (en)
- Karcinosarkom (CS) je vzácný bifázický nádor ženského pohlavního traktu s maligní epitelovou i mezenchymální komponentou. Výskyt neepitelové a nemezenchymální diferenciace je extrémně vzácný. Autoři popisují případ 54 leté ženy, která v minulosti prodělala léčbu karcinomu prsu. Nyní u ní byl nalezen nádor dělohy, který měl histologické, imunohistochemické a ultrastrukturální rysy CS s melanocytární diferenciací. Šlo o polypoidní lézi 7x5,6 cm vyrůstající z endometria a metastazující v dutině břišní ve formě maligního melanomu - nejagresivnější komponenty CS. Přes adjuvantní chemoterapii pacientka zemřela 8 měsíců od primární diagnózy v důsledku generalizace CS. V souladu se současnými poznatky autoři považují melanocytární diferenciaci za důsledek multidivergentní schopnosti diferenciace nádorových kmenových buněk. Diskutována je rovněž možná patogeneze léze a role tamoxifenu v rozvoji nádoru. Doposud byl v literatuře popsán jediný případ CS s melanocytární diferenciací. (cs)
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| Title
| - Carcinosarcoma of the uterus with melanocytic differentiation
- Carcinosarcoma of the uterus with melanocytic differentiation (en)
- Karcinosarkom dělohy s melanocytární diferenciací (cs)
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| skos:prefLabel
| - Carcinosarcoma of the uterus with melanocytic differentiation
- Carcinosarcoma of the uterus with melanocytic differentiation (en)
- Karcinosarkom dělohy s melanocytární diferenciací (cs)
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| skos:notation
| - RIV/00216208:11150/08:00106635!RIV09-MSM-11150___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/08:00106635
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - carcinosarcoma; mixed müllerian tumor; uterus; melanocytic differentiation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Pathology Research and Practice
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Ryška, Aleš
- Špaček, Josef
- Kajo, Karol
- Zubor, Pavol
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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