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| Description
| - Studie byla zacílená na srovnání úspěšnosti léčby antipsychotiky druhé generace ve srovnání s nízkou dávkou haloperidolu. V 50 střediscích čtrnácti zemí byla 498 pacientů náhodně přidělena léčba webovým randomizačním systémem. Pacienti užívali po 12 měsíců haloperidol (1-4 mg denně; n=103), amisulprid (200-800 mg denně, n=104), olanzapin (5-20 mg denně; n=105), quetiapin (200-750 mg denně; n=104), nebo ziprasidon (40-160 mg denně; n=82). Výsledné hodnocení se opítralo o vysazení přiděleného antipsychotika z libovolné příčiny. Během roku vysadilo 63 pacientů (Kaplan-Meierův odhad 72%) na haloperidolu, 32 (40%) na amisulpridu, 30 (33%) na olanzapinu, 51 (53%) na quetiapinu a 31 (45%) na ziprasidonu. Srovnání s haloperidolem ukázalo na nižší riziko vysazení z libovolné příčiny u antipsychotik druhé generace: amisulpiridu, olanzapinu, quetiapinu i ziprasidonu. (cs)
- We aimed to compare the effectiveness of second-generation antipsychotic drugs with that of a low dose of haloperidol, in first-episode schizophrenia.We did an open randomised controlled trial of haloperidol versus second-generation antipsychotic drugs in 14 countries.498 patients were randomly assigned by a web-based online system to haloperidol, amisulpride, olanzapine, quetiapine or ziprasidone; follow-up was at 1 year. The primary outcome measure was all-cause treatment discontinuation. The number of patients who discontinued treatment for any cause within 12 months was 63 (Kaplan-Meier estimate 72%) for haloperidol, 32 (40%) for amisulpride, 30 (33%) for olanzapine, 51 (53%) for quetiapine, and 31 (45%) for ziprasidone. Comparisons with haloperidol showed lower risks for any-cause discontinuation with amisulpride, olanzapine, quetiapine, and ziprasidone.
- We aimed to compare the effectiveness of second-generation antipsychotic drugs with that of a low dose of haloperidol, in first-episode schizophrenia.We did an open randomised controlled trial of haloperidol versus second-generation antipsychotic drugs in 14 countries.498 patients were randomly assigned by a web-based online system to haloperidol, amisulpride, olanzapine, quetiapine or ziprasidone; follow-up was at 1 year. The primary outcome measure was all-cause treatment discontinuation. The number of patients who discontinued treatment for any cause within 12 months was 63 (Kaplan-Meier estimate 72%) for haloperidol, 32 (40%) for amisulpride, 30 (33%) for olanzapine, 51 (53%) for quetiapine, and 31 (45%) for ziprasidone. Comparisons with haloperidol showed lower risks for any-cause discontinuation with amisulpride, olanzapine, quetiapine, and ziprasidone. (en)
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| Title
| - Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial
- Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial (en)
- Úspěšnost antipsychotických léků u první episody schizofrenie a schizofreniformní poruchy: otevřená, znáhodněná, klinická studie (cs)
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| skos:prefLabel
| - Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial
- Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial (en)
- Úspěšnost antipsychotických léků u první episody schizofrenie a schizofreniformní poruchy: otevřená, znáhodněná, klinická studie (cs)
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| skos:notation
| - RIV/00216208:11150/08:00106560!RIV09-MSM-11150___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/08:00106560
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - first episode schizophrenia; second generation antipsychotic drugs; treatment; randomised pragmatic trial (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Galderisi, Silvana
- Libiger, Jan
- Hummer, Martina
- Davidson, Michael
- Boter, Han
- Gaebel, Wolfgang
- Dollfus, Sonia
- Fleischhacker, W Wolfgang
- Gheorghe, Mihai D
- Grobbee, Diederick E
- Hranov, Luchezar G
- Kahn, René S
- Keet, Ireneus PM
- Lindefors, Nils
- Lopéz-Ibor, Juan J
- Peuskens, Joseph
- Riecher-Rőssler, Anita
- Rybakowski, Janusz K
- Vergouwe, Yvonne
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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