About: Zinc alters cytoskeletal integrity and migration in colon cancer cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Zinc has been shown to have inhibitory effects on proliferation and metabolism of malignant colonocytes. Still, there is no information available concerning putative effects of zinc against motility and migration of colon cancer cells. Using fluorescence microscopy, immunoblotting and microfluorimetry we show that treatment with zinc sulfate affected motility, invasiveness, cytoskeletal integrity and expression of selected markers (E-cadherin, catenin, vimentin, tubulin and actin) of invasive SW480 colon tumor cells. These results emphasize the possible multitudinous role of zinc in the process of colon cancer development and hint at the potential of this element in chemoprevention of advanced colorectal carcinoma. Zinc has been shown to have inhibitory effects on proliferation and metabolism of malignant colonocytes. Still, there is no information available concerning putative effects of zinc against motility and migration of colon cancer cells. Using fluorescence microscopy, immunoblotting and microfluorimetry we show that treatment with zinc sulfate affected motility, invasiveness, cytoskeletal integrity and expression of selected markers (E-cadherin, catenin, vimentin, tubulin and actin) of invasive SW480 colon tumor cells. These results emphasize the possible multitudinous role of zinc in the process of colon cancer development and hint at the potential of this element in chemoprevention of advanced colorectal carcinoma. (en) Bylo prokázáno, že zinek má inhibiční účinky na proliferaci a metabolismus maligních kolonocytů. I přesto neexistují informace o jeho účincích na motilitu a migraci těchto buněk. Za pomoci fluorescenční mikroskopie imunoblotingu a mikroflurometrie dokazujeme, že síran zinečnatý ovlivňuje motilitu, invazivitu, integritu cytoskeletu a expresi vybraných markerů (E-kadherin, katenin, vimentin, tubulin a aktin) u invazivních buněk linie SW480. Tyto výsledky podtrhují možnou flexibilní úlohu zinku v procesu kolorektální karcinogeneze a naznačují chemopreventivní potenciál tohoto prvku u rozvinutého kolorektálního karcinomu. (cs)
Title	Zinc alters cytoskeletal integrity and migration in colon cancer cells Zinc alters cytoskeletal integrity and migration in colon cancer cells (en) Zinek ovlivňje integritu a migraci nádorových buněk kolorekta (cs)
skos:prefLabel	Zinc alters cytoskeletal integrity and migration in colon cancer cells Zinc alters cytoskeletal integrity and migration in colon cancer cells (en) Zinek ovlivňje integritu a migraci nádorových buněk kolorekta (cs)
skos:notation	RIV/00216208:11150/08:00106537!RIV09-MSM-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Červinka, Miroslav Rudolf, Emil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	406815
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/08:00106537
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SW480 cells; migration; invasion; cytoskeleton; microtubules (en)
http://linked.open.../riv/klicoveSlovo	SW480 cells migration invasion cytoskeleton microtubules
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[EEFEF3F7BBC6]
http://linked.open...i/riv/nazevZdroje	Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Rudolf, Emil Červinka, Miroslav John, Stanislav Klvačová, Lada
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	1211-4286
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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