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| Description
| - The immunohistochemical exppression of galectin-3 (Gal3), cytokeratin (CK19), neural cell adhesion molecule (NCAM), and E-cadherin (Ecad) was evaluated to assess their use in diagnostics of papillary thyroid carcinoma (PTC) A total of 84 PTCs - 36 classical variants (cPTCs), 26 follicular variants (fPTCs), and 22 papillary microcarcinomas (mPTCs) were studied. A significant difference in CK19 expression was observed between cPTC and both fPTC and mPTC (p<0,001). Furthemore, extrathyroid tumor spread significantly correlated with both level of CK19 expression and loss of Ecad expression (p=0,001, p=0,04). Our findings suggest that Gal3 and CK19 are useful markers for PTC, although decreased CK19 expression in mPTC and fPTC must be considered. Furthemore, CK19 and Ecad may play a role in extrathyroid tumor spread.
- The immunohistochemical exppression of galectin-3 (Gal3), cytokeratin (CK19), neural cell adhesion molecule (NCAM), and E-cadherin (Ecad) was evaluated to assess their use in diagnostics of papillary thyroid carcinoma (PTC) A total of 84 PTCs - 36 classical variants (cPTCs), 26 follicular variants (fPTCs), and 22 papillary microcarcinomas (mPTCs) were studied. A significant difference in CK19 expression was observed between cPTC and both fPTC and mPTC (p<0,001). Furthemore, extrathyroid tumor spread significantly correlated with both level of CK19 expression and loss of Ecad expression (p=0,001, p=0,04). Our findings suggest that Gal3 and CK19 are useful markers for PTC, although decreased CK19 expression in mPTC and fPTC must be considered. Furthemore, CK19 and Ecad may play a role in extrathyroid tumor spread. (en)
- Cílem studie bylo pomocí nepřímé imunohistochemie zjistit expresi galektinu-3 (Gal3), cytokeratinu 19 (CK19), neural cell adhesion molecule (NCAM) a E-cadherinu (Ecad) ve variantách papilárního karcinomu štítné žlázy (PTC) s ohledem na možné využití těchto markerů v bioptické diagnostice. Soubor tvořilo 84 případů - 36 klasických variant PTC (cPTC), 26 folikulárních variant PTC (fPTC) a 22 papilárních mikrokarcinomů (mPTC). V expresi CK19 byl zjištěn signifikantní rozdíl mezi cPTC versus fPTC a mPTC (p<0,001). Dále byla prokázána signifikantní korelace mezi expresí CK19 a ztrátou exprese Ecad ve vztahu k šíření nádoru mimo štítnou žlázu (p=0,001, p=0,04). Detekci exprese Gal3 a CK19 lze tedy doporučit jako pomocné kritérium v daigbnostice PTC, nicméně je třeba upozornit na nižší expersi CK19 ve fPTC a v mPTC. K detailnímu posouzení úlohy CK19 a Ecad při šíření PTC mimo štítnou žlázu je třeba dalších studií. (cs)
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| Title
| - Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma
- Exprese galectinu-3, cytokeratinu 19, neural cell adhesion molecule a E-cadherinu ve variantách papilárního karcinomu štítné žlázy (cs)
- Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma (en)
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| skos:prefLabel
| - Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma
- Exprese galectinu-3, cytokeratinu 19, neural cell adhesion molecule a E-cadherinu ve variantách papilárního karcinomu štítné žlázy (cs)
- Expression of Galectin-3, Cytokeratin 19, Neural Cell Adhesion Molecule and E-cadherin in Certain Variants of Papillary Thyroid Carcinoma (en)
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| skos:notation
| - RIV/00216208:11150/08:00106514!RIV09-MZ0-11150___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/08:00106514
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - papillary thyroid carcinoma; galectin-3; cytokeratin 19; neural cell adhesion molecule; E cadherin (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Česko-slovenská patologie a Soudní lékařství
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Laco, Jan
- Ryška, Aleš
- Čelakovský, Petr
- Čáp, Jan
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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