About: Insights into the oxidative stress response in Frahcisella tularensis LVS and its mutant Delta iglC1+2 by proteomics analysis

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About: Insights into the oxidative stress response in Frahcisella tularensis LVS and its mutant Delta iglC1+2 by proteomics analysis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to find and identify proteins of F. tularensis live vaccine strain induced in the presence of hydrogen peroxide, and to investigate the role of the IglC protein in the regulation of genes expressed upon peroxide stress. The [35S]- radiolabelled protein patterns were examined for both the wild live vaccine strain and its ?iglC1 + 2 mutant defective in synthesis of the IglC protein that was found to be strongly up-regulated during intracellular growth in murine macrophages in vitro and upon exposure to hydrogen peroxide. Globally, we found 21 protein spots whose levels were significantly altered in the presence of hydrogen peroxide in both the wild-type and mutant strains. The aim of this study was to find and identify proteins of F. tularensis live vaccine strain induced in the presence of hydrogen peroxide, and to investigate the role of the IglC protein in the regulation of genes expressed upon peroxide stress. The [35S]- radiolabelled protein patterns were examined for both the wild live vaccine strain and its ?iglC1 + 2 mutant defective in synthesis of the IglC protein that was found to be strongly up-regulated during intracellular growth in murine macrophages in vitro and upon exposure to hydrogen peroxide. Globally, we found 21 protein spots whose levels were significantly altered in the presence of hydrogen peroxide in both the wild-type and mutant strains. (en) Cílem této studie bylo hledat a identifikovat bílkoviny živého vakcinačního kmene Francisely tularensis indukované v přítomnosti peroxidu vodíku a studovat úlohu bílkoviny IglC1 při regulaci genů exprimovaných při peroxidovém stresu. U divokého živého vakcinačního kmene a jeho IglC 1+ 2 mutanta defektivního v syntéze bílkoviny IglC1, která je zvýšeně exprimována v přítomnosti peroxidu vodíku a během intracelulárního růstu v myších makrofázích in vitro byly studovány charakteristiky [35S] radioznačené bílkoviny. Celkově jsme nalezli 21 bílkovinových bodů jejichž hladiny byly významně změněny v přítomnosti peroxidu vodíku u obou použitých kmenů – divokého a mutantního. (cs)
Title	Insights into the oxidative stress response in Frahcisella tularensis LVS and its mutant Delta iglC1+2 by proteomics analysis Porozumění odpovědi na oxidativní stres u Francisella tularensis LVS and mutantního kmene Delta iglC1+2 pomocí proteomické analýzy (cs) Insights into the oxidative stress response in Frahcisella tularensis LVS and its mutant Delta iglC1+2 by proteomics analysis (en)
skos:prefLabel	Insights into the oxidative stress response in Frahcisella tularensis LVS and its mutant Delta iglC1+2 by proteomics analysis Porozumění odpovědi na oxidativní stres u Francisella tularensis LVS and mutantního kmene Delta iglC1+2 pomocí proteomické analýzy (cs) Insights into the oxidative stress response in Frahcisella tularensis LVS and its mutant Delta iglC1+2 by proteomics analysis (en)
skos:notation	RIV/00216208:11150/07:00004052!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany	47;54
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Stulík, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	426816
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/07:00004052
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Insights; oxidative; stress; response; Frahcisella; tularensis; mutant; Delta; iglC1+2; proteomics; analysis (en)
http://linked.open.../riv/klicoveSlovo	mutant analysis response stress Frahcisella iglC1+2 tularensis oxidative proteomics Delta Insights
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1558C05D1720]
http://linked.open...i/riv/nazevZdroje	FEMS Microbiology Letters
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	246
http://linked.open...iv/tvurceVysledku	Stulík, Jiří
issn	0378-1097
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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