About: CD40 soluble ligang and acute coronary syndromes     Goto   Sponge   NotDistinct   Permalink

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Description
  • Současný výzkum se soutředí na molekuly, kterými bychom mohli detekovat ranná stádia akutních koronárních syndromů jako jsme schopní s troponiny. Solubilní CD40L představuje unikátní spojení mezi trombózou a lokálním zanětlivým procesem. Podle klinických údajů jsou jeho zvýšené hladiny spojené s vysokým rizikem smrtelného infarktu myokardu, chronického srdečního selhání nebo rekurentního infarktu u pacientů s akútním koronárním syndromem. Mohl by oddálit pacienty, kteří by profitovali z terapie IIb/IIIa antagonisty a stratifikovat riziko trombózy před plánovanou implantací stentu. K definitivnímu stanovisku jsou potřebné další studie. (cs)
  • Current research is focused on the new cardiac markers that allow detect earlier stages of acute coronary syndromes than is possible with troponins. One of the most promising is CD40 ligand. Clinical data showed that higher levels of sCD40L are associated with a high risk of cardiovascular events. Elevation of soluble CD40 ligand identifies the subgroup of patients who are likely to benefit from antiplatelet treatment with IIb/IIIa antagonists. This marker can be usefull for the assessment of risk stratification before planning stent implantation. Future investigation should include large, well-designed prospective observational cohort studies of patients in risk of ACS in order to evaluate the performance of sCD40L as a diagnostic test for ACS.
  • Current research is focused on the new cardiac markers that allow detect earlier stages of acute coronary syndromes than is possible with troponins. One of the most promising is CD40 ligand. Clinical data showed that higher levels of sCD40L are associated with a high risk of cardiovascular events. Elevation of soluble CD40 ligand identifies the subgroup of patients who are likely to benefit from antiplatelet treatment with IIb/IIIa antagonists. This marker can be usefull for the assessment of risk stratification before planning stent implantation. Future investigation should include large, well-designed prospective observational cohort studies of patients in risk of ACS in order to evaluate the performance of sCD40L as a diagnostic test for ACS. (en)
Title
  • CD40 soluble ligang and acute coronary syndromes
  • CD40 soluble ligang and acute coronary syndromes (en)
  • Solubilní ligand CD40 a akutní koronární syndromy (cs)
skos:prefLabel
  • CD40 soluble ligang and acute coronary syndromes
  • CD40 soluble ligang and acute coronary syndromes (en)
  • Solubilní ligand CD40 a akutní koronární syndromy (cs)
skos:notation
  • RIV/00216208:11150/07:00003973!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany
  • 61;64
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 412781
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/07:00003973
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • soluble; ligang; acute; coronary; syndromes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [7BF2C4E65436]
http://linked.open...i/riv/nazevZdroje
  • Intervenční a akutní kardiologie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 6
http://linked.open...iv/tvurceVysledku
  • Pudil, Radek
  • Vojáček, Jan
  • Šťásek, Josef
issn
  • 1213-807X
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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