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| rdf:type
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| Description
| - Kvůli nezralosti specifické i nespecifické imunity jsou novorozenci ohroženi vážnou infekcí. Definice rizikové skupiny je vágní,klinické známky infekce jsou nespecifické a běžné labortorní známky nejsou tak užitečné, jako v pozdějším věku, zejména kvůli jejich opožděné reakci. Při pokusu o nalezení časných, senzitivních a specifických známek infekce jsme stanovili definovanou sadu povrchových znaků a humorálních faktorů v pupečníkové krvi. Bylo zaznamenáno několik rozdílů- děti v rizikové skupině měly vyšší proporci C D19+/23+,CD16+/64+, CD45RO buněk a vyšší hladiny IL-6.Je slibné, že již při porodu lze zaznamenat známky reakce na infekci a že sledování těchto známek by mohlo umožnit identifikaci dětí, které potřebují antibiotickou léčbu, a zároveň snížit nadbytečnou antibiotickou terapii. (cs)
- Due to immaturity of both specific and non-specific immune mechanism, neonates are at risk of serious infection. The risk group definition is vague, clinical signs are non-specific and common laboratory markers are not as useful as in later ages, especially due to delayed reactions. In an attempt to find early, sensitive and specific markers, we assessed a defined set of surface leukocyte markers and humoral factors in cord blood. Severel differences were noted - children in the risk group had a higher proportion of CD19+/23+, CD16+/64+, CD45RO cells and higher levels of IL-6. We find it promising that already at birth there are notable signs of reaction to infection and that a follow-up of a set of infectious markers could be useful to identity the children in need of antibiotic treatment and for diminishing unnecessary treatment.
- Due to immaturity of both specific and non-specific immune mechanism, neonates are at risk of serious infection. The risk group definition is vague, clinical signs are non-specific and common laboratory markers are not as useful as in later ages, especially due to delayed reactions. In an attempt to find early, sensitive and specific markers, we assessed a defined set of surface leukocyte markers and humoral factors in cord blood. Severel differences were noted - children in the risk group had a higher proportion of CD19+/23+, CD16+/64+, CD45RO cells and higher levels of IL-6. We find it promising that already at birth there are notable signs of reaction to infection and that a follow-up of a set of infectious markers could be useful to identity the children in need of antibiotic treatment and for diminishing unnecessary treatment. (en)
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| Title
| - Surface activation leukocyte markers and humoral factors in cord blood of newborns at risk of early infection
- Surface activation leukocyte markers and humoral factors in cord blood of newborns at risk of early infection (en)
- Povrchové aktivační leukocytární znaky a humorální faktory v pupečníkové krvi novorozenců s rizikem časné infekce (cs)
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| skos:prefLabel
| - Surface activation leukocyte markers and humoral factors in cord blood of newborns at risk of early infection
- Surface activation leukocyte markers and humoral factors in cord blood of newborns at risk of early infection (en)
- Povrchové aktivační leukocytární znaky a humorální faktory v pupečníkové krvi novorozenců s rizikem časné infekce (cs)
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| skos:notation
| - RIV/00216208:11150/07:00003772!RIV08-MZ0-11150___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/07:00003772
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - newborns; early infection; leukocyte surface markers; interleukin; neopterin; procalcitonin (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Acta Medica (Hradec Králové)
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Rozsíval, Pavel
- Vokurková, Doris
- Pařízková, Eva
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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