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Description
  • Podávání antipsychotik se zdá být ve vztahu ke zvýšenému riziku žilního tromboembolismu a cerebrovaskulárním nežádoucím účinkům. Zatím jsou biologické mechanismy těchto nežádoucích účinků neznámé. Při léčbě antipsychotiky však vzrůstá hladina prolaktinu. Prolaktin je koaktivátorem srážení krevních destiček. Představuje tedy rizikový faktor pro arteriální a žilní trombózu. Krátce shrnujeme údaje o roli hyperprolaktinemie v patogenezi srážení krevních destiček. (cs)
  • Administration of antipsychotics appears to be related to increased risk of venous thromboembolism and cerebrovascular side effects. The biological mechanism responsible for this possible adverse drug reaction is unknown, but there is a growing number of elucidating hypotheses. Treatment with antipsychotics is a asssociated with elevation of prolactin level. Prolactin has recently been recognized as potent platelet aggregation co-activator, and have therefore been postulated as an addditional risk factor for both arterial and venous thrombosis. We briefly review the arguments for the role of hyperprolactinemia in pathogenesis of platelet aggregation.
  • Administration of antipsychotics appears to be related to increased risk of venous thromboembolism and cerebrovascular side effects. The biological mechanism responsible for this possible adverse drug reaction is unknown, but there is a growing number of elucidating hypotheses. Treatment with antipsychotics is a asssociated with elevation of prolactin level. Prolactin has recently been recognized as potent platelet aggregation co-activator, and have therefore been postulated as an addditional risk factor for both arterial and venous thrombosis. We briefly review the arguments for the role of hyperprolactinemia in pathogenesis of platelet aggregation. (en)
Title
  • Prolactin as a factor for increased platelet aggregation
  • Prolactin as a factor for increased platelet aggregation (en)
  • Prolaktin jako faktor zvýšeného srážení krevních destiček (cs)
skos:prefLabel
  • Prolactin as a factor for increased platelet aggregation
  • Prolactin as a factor for increased platelet aggregation (en)
  • Prolaktin jako faktor zvýšeného srážení krevních destiček (cs)
skos:notation
  • RIV/00216208:11150/07:00003697!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany
  • 101;106
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021620816), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 445302
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/07:00003697
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • prolactin; hyperprolactinemia; platelet activation; platelet aggregation; antipsychotics; venous thrombosis; cerebrovascular complications (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SE - Švédské království
http://linked.open...ontrolniKodProRIV
  • [0E30A643391A]
http://linked.open...i/riv/nazevZdroje
  • Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Hosák, Ladislav
  • Malý, Radovan
  • Masopust, Jiří
  • Urban, Aleš
  • Kalnická, Dita
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-780X
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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