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rdf:type
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Description
| - Programovaná buněčná smrt hraje důležitou roli v řadě biologických procesů, jako je např. mofrogeneze, odstraňování nepotřebných či nebezpečných buněk, tkáňová homeostáza. Proteiny Bcl-2 rodiny jsou charakterizovány jako klíčoví regulátoři apoptického procesu. V tomto článku se kromě shrnutí nejnovějších poznatků v oboru zabýváme tím, jak interagují mezi sebou a jak přenášejí a ovlivňují smrtící signály z okolí buňky. Zde přirovnáváme proteiny Bcl-2 k inspektorům a dozorcům, jelikož dohlíží na 'výrobní' proces apoptózy a určují zda buňka zahyne či přežije. (cs)
- Programmed cell death plays an integral role in a variety of biological events, e.g. morphogenesis, removal of unwanted or harmfull cells, tissue homeostasis etc. Members of Bcl-2 protein family have been described as the key regulators of the apoptotic process. In this paper, besides reviewing the newest information in this field, we focused on how do they interact among each other and on the way they sense and influence the death signals from environment. Here, we compare Bcl-2 family to inspectors and superintendents since they supervise the manufacturing process of cell death and they determine whether the cell will die or it will resist and survive.
- Programmed cell death plays an integral role in a variety of biological events, e.g. morphogenesis, removal of unwanted or harmfull cells, tissue homeostasis etc. Members of Bcl-2 protein family have been described as the key regulators of the apoptotic process. In this paper, besides reviewing the newest information in this field, we focused on how do they interact among each other and on the way they sense and influence the death signals from environment. Here, we compare Bcl-2 family to inspectors and superintendents since they supervise the manufacturing process of cell death and they determine whether the cell will die or it will resist and survive. (en)
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Title
| - Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents
- Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents (en)
- Apoptická mašinére: proteiny rodiny Bcl-2 v roli inspektorů a dozorčích (cs)
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skos:prefLabel
| - Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents
- Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents (en)
- Apoptická mašinére: proteiny rodiny Bcl-2 v roli inspektorů a dozorčích (cs)
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skos:notation
| - RIV/00216208:11150/06:00004303!RIV07-MSM-11150___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/06:00004303
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - apoptosis; Bcl-2 family proteins; mitochondria; caspases (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Acta Medica (Hradec Králové)
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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