About: Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents     Goto   Sponge   NotDistinct   Permalink

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Description
  • Programovaná buněčná smrt hraje důležitou roli v řadě biologických procesů, jako je např. mofrogeneze, odstraňování nepotřebných či nebezpečných buněk, tkáňová homeostáza. Proteiny Bcl-2 rodiny jsou charakterizovány jako klíčoví regulátoři apoptického procesu. V tomto článku se kromě shrnutí nejnovějších poznatků v oboru zabýváme tím, jak interagují mezi sebou a jak přenášejí a ovlivňují smrtící signály z okolí buňky. Zde přirovnáváme proteiny Bcl-2 k inspektorům a dozorcům, jelikož dohlíží na 'výrobní' proces apoptózy a určují zda buňka zahyne či přežije. (cs)
  • Programmed cell death plays an integral role in a variety of biological events, e.g. morphogenesis, removal of unwanted or harmfull cells, tissue homeostasis etc. Members of Bcl-2 protein family have been described as the key regulators of the apoptotic process. In this paper, besides reviewing the newest information in this field, we focused on how do they interact among each other and on the way they sense and influence the death signals from environment. Here, we compare Bcl-2 family to inspectors and superintendents since they supervise the manufacturing process of cell death and they determine whether the cell will die or it will resist and survive.
  • Programmed cell death plays an integral role in a variety of biological events, e.g. morphogenesis, removal of unwanted or harmfull cells, tissue homeostasis etc. Members of Bcl-2 protein family have been described as the key regulators of the apoptotic process. In this paper, besides reviewing the newest information in this field, we focused on how do they interact among each other and on the way they sense and influence the death signals from environment. Here, we compare Bcl-2 family to inspectors and superintendents since they supervise the manufacturing process of cell death and they determine whether the cell will die or it will resist and survive. (en)
Title
  • Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents
  • Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents (en)
  • Apoptická mašinére: proteiny rodiny Bcl-2 v roli inspektorů a dozorčích (cs)
skos:prefLabel
  • Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents
  • Apoptotic machinery: the Bcl-2 proteins in the role of inspectors and superintendents (en)
  • Apoptická mašinére: proteiny rodiny Bcl-2 v roli inspektorů a dozorčích (cs)
skos:notation
  • RIV/00216208:11150/06:00004303!RIV07-MSM-11150___
http://linked.open.../vavai/riv/strany
  • 13;18
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 465748
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/06:00004303
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • apoptosis; Bcl-2 family proteins; mitochondria; caspases (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [731F4AA45C8A]
http://linked.open...i/riv/nazevZdroje
  • Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 49
http://linked.open...iv/tvurceVysledku
  • Tichý, Aleš
http://linked.open...n/vavai/riv/zamer
issn
  • 1211-4286
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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