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Description
| - In this study the cardioprotective effects of the novel lipophilic iron chelator against chronic anthracycline cardiotoxicity were investigated. Using 10 mg/kg of the chelator administered 30 min before the every daunorubicin dose the significant cardioprotection was obtained (as shown by prevention of cardiac-related deaths, improved functional, biochemical and morphological parameters). On the other hand escalation of the dose to the 25 mg/kg did not improved cardiovascular parameters, on the contrary, the cardioprotective potential was lost and early extracardiac toxicity was observed.
- In this study the cardioprotective effects of the novel lipophilic iron chelator against chronic anthracycline cardiotoxicity were investigated. Using 10 mg/kg of the chelator administered 30 min before the every daunorubicin dose the significant cardioprotection was obtained (as shown by prevention of cardiac-related deaths, improved functional, biochemical and morphological parameters). On the other hand escalation of the dose to the 25 mg/kg did not improved cardiovascular parameters, on the contrary, the cardioprotective potential was lost and early extracardiac toxicity was observed. (en)
- V této studii byly sledovány kardioprotektivní účinky nového chelátoru železa vůči antracycklinové kardiotoxicitě. Chelátor podaný v dávce 10 mg/kg 30 min před daunorubicinem navodil signifikantní kardioprotekci (jak je patrno z prevence kardiální mortality, zlepšení funkčních biochemických a morfologických parametrů). Na druhou stranu, zvýšení dávky na 25 mg/kg nevedlo ke zlepšení kardiovaskulárních parametrů, naopak, kardioprotektivní potenciál vymizel a byla pozorována časná extrakardiální toxicita. (cs)
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Title
| - Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity
- Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity (en)
- Kardioprotektivní účinky nového chelátoru železa, pyridoxal 2-chlorbenzoyl hydrazonu, na modelu daunorubicinem-indukované kardiotoxicity u králíka (cs)
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skos:prefLabel
| - Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity
- Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity (en)
- Kardioprotektivní účinky nového chelátoru železa, pyridoxal 2-chlorbenzoyl hydrazonu, na modelu daunorubicinem-indukované kardiotoxicity u králíka (cs)
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skos:notation
| - RIV/00216208:11150/06:00004259!RIV07-MSM-11150___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GP305/05/P156), V, Z(MSM0021620820)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/06:00004259
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cardiotoxicity; cardioprotection; iron chelator; pyridoxal 2-chlorobenzoyl hydrazone; anthracycline (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Pharmacology and Experimental Therapeutics
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Adamcová, Michaela
- Geršl, Vladimír
- Popelová, Olga
- Štěrba, Martin
- Mazurová, Yvona
- Potáčová, Anna
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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