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| rdf:type
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| Description
| - Mezenchymové kmenové buňky (MKB) jsou vzácné buněčné populace osídlující různé tkáně a orgány (např. kostní dřeň), schopné diferencovat ve specializované tkáně jakými jsou např. kost, chrupavka a tuková tkáň. Byly charakterizovány mnohem primitivnější progenitorové buňky, které daly vzniknout buňkám viscerálního mezodermu. Tyto buněčné typy byly pojmenovány MPB (mezenchymové progenitorové buňky. Cílem naší práce bylo charakterizovat a porovnat základní biologické charakteristiky a spontánní diferenciační potenciál dvou rozdílných buněčných typů (MKB a MPB) izolovaných z kostní dřeně lidských obratlových těl. Výsledky naší práce prokázaly, že MPB mohou být expandovány přes tzv. Hayflickův limit a liší se od MKB morfologicky, biologickými i fenotypickými charakteristikami. Pro vysokou proliferační aktivitu a široký diferenciační potenciál jsou MPB atraktivním zdrojem dospělých kmenových buněk pro terapeutické použití. (cs)
- Mesenchymal Stem Cells (MSCs) are rare elements living in various organs (e.g. bone marrow), able to differentiate into specialized tissues, such as bone, cartilage and adipocytes. More primitive progenitor cells were characterized, able to give rise not only to limb-bud mesoderm, but also to cells of visceral mesoderm. Those cells were named mesodermal progenitor cells (MPCs). The aim of our study was to characterize and compare the biological properties and spontaneous differentiation potential of two different cell types (MSCs and MPCs) isolated from the human vertebral body bone marrow. The results of our experiments proved that the MPCs can be expanded beyond Hayflick's limit and differed from MSCs in morphology, biological and phenotypic characteristics. Because of their high proliferative and differentiation potential, MPCs can become more attractive source of adult stem cells for therapeutic purposes.
- Mesenchymal Stem Cells (MSCs) are rare elements living in various organs (e.g. bone marrow), able to differentiate into specialized tissues, such as bone, cartilage and adipocytes. More primitive progenitor cells were characterized, able to give rise not only to limb-bud mesoderm, but also to cells of visceral mesoderm. Those cells were named mesodermal progenitor cells (MPCs). The aim of our study was to characterize and compare the biological properties and spontaneous differentiation potential of two different cell types (MSCs and MPCs) isolated from the human vertebral body bone marrow. The results of our experiments proved that the MPCs can be expanded beyond Hayflick's limit and differed from MSCs in morphology, biological and phenotypic characteristics. Because of their high proliferative and differentiation potential, MPCs can become more attractive source of adult stem cells for therapeutic purposes. (en)
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| Title
| - Mesenchymal stem cells isolated from the human bone marrow: Cultivation, phenotypisation and changes in proliferation kinetics
- Mezenchymové kmenové buňky izolované z lidské kostní dřeně: Jejich kultivace, fenotypizace a změny biologických charakteristik (cs)
- Mesenchymal stem cells isolated from the human bone marrow: Cultivation, phenotypisation and changes in proliferation kinetics (en)
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| skos:prefLabel
| - Mesenchymal stem cells isolated from the human bone marrow: Cultivation, phenotypisation and changes in proliferation kinetics
- Mezenchymové kmenové buňky izolované z lidské kostní dřeně: Jejich kultivace, fenotypizace a změny biologických charakteristik (cs)
- Mesenchymal stem cells isolated from the human bone marrow: Cultivation, phenotypisation and changes in proliferation kinetics (en)
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| skos:notation
| - RIV/00216208:11150/06:00004118!RIV07-MSM-11150___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/06:00004118
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - bone marrow stromal cells; mesenchymal stem cells; mesodermal progenitor cells; long-term culture; osteogenesis; chondrogenesis; adipogenesis; proliferation kinetics (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Acta Medica (Hradec Králové)
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Karbanová, Jana
- Mokrý, Jaroslav
- Soukup, Tomáš
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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