About: Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture

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About: Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Práce hodnotí protektivní účinek S-adenosylmethioninu (SAMe) v koncentraci 50 a 100 mg/l na galaktosaminem navozené poškození hepatocytů potkana v primární kultuře. Ke stanovení cytotoxicity byla hodnocena aktivita laktátdehydrogenázy v médiu, obsah glutathionu v hepatocytech sloužil k posouzení antioxidačního stavu hepatocytů. Funkční kapacita hepatocytů byla posuzována z produkce urey a syntézy albuminu. SAMe, především jeho vyšší dávka, působil protektivně na hepatocyty vystavené 40 mM galaktosaminu. V mechanizmu tohoto účinku pravděpodobně hraje úlohu zmírnění poškození cytoplazmatické membrány a zvýšená produkce glutathionu. (cs) The protective effect of S-adenosylmethionine (SAMe) in concentrations of 50 and 100 mg/l was tested on D-galactosamine-induced injury of rat hepatocytes in primary culture. Lactate dehydrogenase activity in medium and glutathione content in hepatocytes were measured to analyse hepatocyte injury and antioxidative conditions of hepatocytes. Evaluation of urea production and albumin synthesis allowed to determine the functional capacity of hepatocytes. Our findings indicate the beneficial effect of SAMe, especially of higher concentration, on hepatocytes exposed to 40 mM galactosamine that seems to be associated with reduction of plasma membrane damage and increased synthesis of glutathione. The protective effect of S-adenosylmethionine (SAMe) in concentrations of 50 and 100 mg/l was tested on D-galactosamine-induced injury of rat hepatocytes in primary culture. Lactate dehydrogenase activity in medium and glutathione content in hepatocytes were measured to analyse hepatocyte injury and antioxidative conditions of hepatocytes. Evaluation of urea production and albumin synthesis allowed to determine the functional capacity of hepatocytes. Our findings indicate the beneficial effect of SAMe, especially of higher concentration, on hepatocytes exposed to 40 mM galactosamine that seems to be associated with reduction of plasma membrane damage and increased synthesis of glutathione. (en)
Title	Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture (en) Protektivní účinek S-adenosylmethioninu vůči galaktosaminem-navozenému poškození hepatocytů potkana v primární kultuře (cs)
skos:prefLabel	Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture (en) Protektivní účinek S-adenosylmethioninu vůči galaktosaminem-navozenému poškození hepatocytů potkana v primární kultuře (cs)
skos:notation	RIV/00216208:11150/06:00004033!RIV07-MSM-11150___
http://linked.open.../vavai/riv/strany	551;560
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Roušar, Tomáš Staňková, Pavla Kremláček, Jan Červinková, Zuzana Kučera, Otto Rudolf, Emil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	495678
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/06:00004033
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	S-adenosylmethionine; galactosamine; hepatocytes in vitro (en)
http://linked.open.../riv/klicoveSlovo	S-adenosylmethionine galactosamine hepatocytes in vitro
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E0FF33AB4DD5]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Rudolf, Emil Roušar, Tomáš Kučera, Otto Lotková, Halka Červinková, Zuzana Křiváková, Pavla
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0862-8408
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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